PXD061045

PXD061045 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterization of the effect of CBD in animal models of PWA
Description	The effect of CBD was investigated in a preclinical model of PCOS generated by chronic exposure of female mice to DHT from weaning onwards. To exacerbate the metabolic complications in this model, PWA mice were fed a high-fat diet (HFD) for 18 weeks before initiation of the pharmacological treatments. This model phenocopies a subtype of women with this condition who suffer metabolic comorbidities. PWA exacerbated the metabolic disturbances induced by the high-fat diet (HFD), as HFD-fed, non-androgenized female mice exhibited a smaller increase in body weight (BW) compared to androgenized females on the same diet before treatment initiation (Fig. 1A). Daily treatment with CBD for 28 days caused a clear reduction of BW through the treatment period. This datset contains the results of a proteomic characterization of the livers from control mice, PWA mice and CBD treated mice.
HostingRepository	PRIDE
AnnounceDate	2025-08-05
AnnouncementXML	Submission_2025-08-05_03:46:00.676.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Garrido
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-21 05:03:30	ID requested
⏵ 1	2025-08-05 03:46:01	announced

Ponce-D, í, az FJ, Ruiz-Pino F, Garrido-Rodriguez M, Prados-Gonz, á, lez ME, Uceda-Rodriguez E, Cerero-Tejero L, Guerrero-Ruiz Y, Sanchez-Garrido MA, Mu, ñ, oz E, Tena-Sempere M, Cannabidiol improves metabolic profiles and alleviates liver inflammation and fibrosis in conditions of androgenic obesity and polycystic ovary syndrome. Diabetes Obes Metab, 27(10):6027-6031(2025) [pubmed]

10.1111/dom.16602;

submitter keyword: Androgenization,Liver, Cannabidiol, Obesity

Eduardo Munoz
contact affiliation	Maimonides Biomedical Research Institute of Córdoba, Reina Sofía University Hospital, Department of Cell Biology, Physiology and Immunology, University of Córdoba, Avda Menéndez Pidal s/n., 14004, Córdoba, Spain
contact email	fi1muble@uco.es
lab head
Martin Garrido
contact affiliation	Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany
contact email	martin.garrido@uni-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD061045

PRIDE project URI

• PRIDE
  1. PXD061045
     1. Label: PRIDE project
     2. Name: Proteomic characterization of the effect of CBD in animal models of PWA