PXD061029
PXD061029 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integration of CRISPR-Cas9 Screens and Multi-Omics Profiling Reveals CHD7-ANGPT1 as a Novel Multi-Drug Resistance Axis in AML |
| Description | To explore how the loss of function of CHD7 leads to drug resistance in acute myeloid leukemia (AML) cells, we investigated the transcriptional programs regulated by CHD7 in OCI-AML2 cells under different drug treatment conditions. This study aims to uncover the role of CHD7 in drug sensitivity and resistance, providing a theoretical basis for developing new therapeutic strategies. |
| HostingRepository | iProX |
| AnnounceDate | 2025-02-21 |
| AnnouncementXML | Submission_2025-02-20_18:43:47.366.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tingting Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-02-20 18:43:34 | ID requested | |
| ⏵ 1 | 2025-02-20 18:43:47 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Acute myeloid leukemia, CHD7, Gilteritinib, Venetoclax, Angiopoietin-1 |
Contact List
| Hong Wang | |
|---|---|
| contact affiliation | Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | wanghong@ihcams.ac.cn |
| lab head | |
| Tingting Zhang | |
| contact affiliation | Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College |
| contact email | ztt_000@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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