PXD060999

PXD060999 is an original dataset announced via ProteomeXchange.

Title	Intergenerational control of ribosome levels upon dietary restriction
Description	Living organisms adjust their proteome in response to nutritional conditions, but how these changes are transmitted across generations remains unclear. While unicellular organisms can inherit proteome states through symmetric division, multicellular organisms face limitations due to the soma-germline barrier. Using TMT-based quantitative proteomics, we investigated the intergenerational effects of dietary restriction (DR) on proteome allocation in C. elegans. While DR caused substantial proteome-wide changes within a generation, most of these changes were reset in the next generation. However, ribosomal proteins remained significantly reduced in progeny of DR mothers. This ribosomal reduction leads to an initial growth delay when encountering nutrient-rich conditions. This dataset provides a comprehensive resource to explore how proteome changes induced by DR are inherited across generations and to identify regulatory factors involved in ribosome inheritance and growth adaptation.
HostingRepository	PRIDE
AnnounceDate	2026-02-10
AnnouncementXML	Submission_2026-02-10_10:36:04.241.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frank Stein
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: NEWT:6239;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-20 00:06:21	ID requested
⏵ 1	2026-02-10 10:36:04	announced

Dataset with its publication pending

submitter keyword: intergenerational, ribosome,dietary restriction, proteome inheritance

Benjamin Daniel Towbin
contact affiliation	Institute of Cell Biology, University of Bern, Bern, Switzerland
contact email	benjamin.towbin@unibe.ch
lab head
Frank Stein
contact affiliation	EMBL
contact email	frank.stein@embl.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD060999
     1. Label: PRIDE project
     2. Name: Intergenerational control of ribosome levels upon dietary restriction