PXD060989
PXD060989 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mouse Testis IP-MS Analysis of TEX44 Interacting Proteins |
| Description | Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine palmitoyltransferase 1B (CPT1B) to form a mitochondrial glue, anchoring adjacent mitochondria and facilitating the assembly of the sperm-specific mitochondrial sheath. |
| HostingRepository | iProX |
| AnnounceDate | 2025-02-20 |
| AnnouncementXML | Submission_2025-02-19_22:37:05.739.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Siyu Liu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-02-19 22:36:51 | ID requested | |
| ⏵ 1 | 2025-02-19 22:37:06 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Mouse, Testis, IP-MS |
Contact List
| Mingxi Liu | |
|---|---|
| contact affiliation | Nanjing Medical University |
| contact email | mingxi.liu@njmu.edu.cn |
| lab head | |
| Siyu Liu | |
| contact affiliation | Nanjing Medical University |
| contact email | njmulsy2017@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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