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PXD060940

PXD060940 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCocktail Chemical Labeling for In-Depth Surfaceome Profiling
DescriptionWe report a Ruthenium (Ru)-catalyzed cocktail labeling strategy that offers high catalytic efficiency and deeper proteome coverage through a straightforward “mix and lighten” workflow. Our approach uses a highly efficient transition metal complex (TMC)-based catalyst, along with two compatible biotin probes for biased substrates. Our results highlight the potential roles of many previously underestimated CSPs. We provide solid and detailed evidence supporting the efficacy of our method, demonstrating the advantages and uniqueness of Ru-based proximity labeling. This 'cocktail labeling' concept mitigates biases from different labeling methods, broadening substrate scopes and potentially inspiring advancements in other proximity labeling methods.
HostingRepositoryiProX
AnnounceDate2025-02-19
AnnouncementXMLSubmission_2025-02-18_19:36:39.355.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYun Ge
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-02-18 19:36:19ID requested
12025-02-18 19:36:39announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Ruthenium, photocatalysis, cell surface proteome
Contact List
Yun Ge
contact affiliationShenzhen Bay Laboratory
contact emailgeyun@szbl.ac.cn
lab head
Yun Ge
contact affiliationShenzhen Bay Laboratory
contact emailgeyun@szbl.ac.cn
dataset submitter
Full Dataset Link List
iProX dataset URI