PXD060896

PXD060896 is an original dataset announced via ProteomeXchange.

Title	Mechanisms of pathogenic podocin in Nephrotic Syndrome reveal discrete trafficking and degradation Pathways
Description	Nephrotic syndrome is a severe disease that significantly impairs kidney function, potentially leading to renal failure and a high mortality rate. Recent studies have shown that mutations in the kidney-specific protein Podocin are closely associated with the onset of this disease, with the R138Q-Podocin mutation being particularly implicated in its pathogenesis. This study aims to compare the interactome of R138Q-Podocin with that of wild-type (WT) Podocin to elucidate its pathogenic mechanisms and explore potential therapeutic strategies.
HostingRepository	iProX
AnnounceDate	2025-02-17
AnnouncementXML	Submission_2025-02-17_18:30:27.889.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peichen Lu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion ETD

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-17 18:30:07	ID requested
⏵ 1	2025-02-17 18:30:28	announced

Dataset with its publication pending

submitter keyword: kidney disease, podocin, nephrotic syndrome, protein mutagenesis

Gavin I Welsh
contact affiliation	University of Bristol
contact email	g.i.welsh@bristol.ac.uk
lab head
Peichen Lu
contact affiliation	University of Bristol
contact email	hg20165@bristol.ac.uk
dataset submitter

iProX dataset URI