PXD060893

PXD060893 is an original dataset announced via ProteomeXchange.

Title	Plasma proteomic changes in cats diagnosed with hypertrophic cardiomyopathy (HCM)
Description	Feline HCM is the most common cardiac disease in cats and has a complex and not fully elucidated pathophysiology. An initial chronic, low-grade inflammation, characterised by increased levels of pro-inflammatory cytokines, inflammatory cell infiltrates and, often, increased fibrosis occurs, but the initiating factor/s that trigger this early and sustained low grade inflammation are currently unknown. This study compared the plasma proteome of cats diagnosed with fHCM disease using SWATH MS proteomics with the aims to identify novel biomarkers for fHCM and to further elucidate disease pathogenesis. A total of 20 cats were enrolled in this study in two groups ie., healthy control (n=10), and HCM (n=10) respectively. Cats in HCM group, were diagnosed by echocardiography procedure and disease status was determined by a registered veterinary cardiologist. Following proteomic analysis, majority of the dysregulated proteins were associated innate and humoral response including complement C7, C9, and properdin proteins suggesting complement activation plays a vital role in HCM. Other dysregulated proteins were involved in blood coagulation including fibrinogen, fibulin -1; proteins associated with lipid metabolism, inflammation and extracellular matrix remodelling including apolipoprotein M, angiotensin-converting enzyme, transthyretin, plasminogen. These findings may provide an additional tool for diagnosis and insights of pathophysiological changes in fHCM
HostingRepository	PRIDE
AnnounceDate	2026-08-25
AnnouncementXML	Submission_2026-08-25_02:54:37.953.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Halley Ravuri
SpeciesList	scientific name: Felis chaus x Felis catus; NCBI TaxID: NEWT:2576912;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-17 17:59:02	ID requested
⏵ 1	2026-08-25 02:54:38	announced

Ravuri HG, Daniels AL, Sadowski P, Mills PC, Understanding Pathophysiological Complexity of Feline Hypertrophic Cardiomyopathy Using SWATH-MS Plasma Proteomics. Animals (Basel), 16(5):(2026) [pubmed]

10.3390/ani16050781;

submitter keyword: proteomics, DIA, feline,cat, plasma

Paul Mills
contact affiliation	University of Queensland School of Veterinary Science
contact email	p.mills@uq.edu.au
lab head
Halley Ravuri
contact affiliation	Postdoctoral Research Fellow, School of Biomedical Sciences, UQ
contact email	h.ravuri@uq.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD060893
     1. Label: PRIDE project
     2. Name: Plasma proteomic changes in cats diagnosed with hypertrophic cardiomyopathy (HCM)