PXD060808

PXD060808 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Aloin Protects Against UVB-Induced Apoptosis
Description	This study comprehensively investigates the photoprotective effects of aloin against UVB-induced damage in HaCaT cells, elucidating its antioxidant capacity and its role in preventing cellular apoptosis. The proteomic effect of 50 μg/mL aloin on HaCaT cell damage induced by UVB was evaluated through comparative protein expression. Compared to control cells, UVB irradiation significantly altered protein expression in HaCaT cells, with 64 proteins upregulated and 236 proteins downregulated. In cells treated with both UVB and aloin, 79 proteins were upregulated and 84 proteins were downregulated compared to the UVB-only group. Proteomic analysis showed that aloin modulated the expression of proteins involved in critical signaling pathways, including PI3K-Akt, p53, TGF-β and pathways in cancer, promoting cell survival. Aloin upregulated proteins associated with cell cycle regula-tion and antioxidant responses, such as CCND3, GSTM4, GNA12, SKIL, YWHAZ, and PKN3 while downregulating pro-apoptotic protein FOXO3.
HostingRepository	PRIDE
AnnounceDate	2025-08-04
AnnouncementXML	Submission_2025-08-03_16:19:00.505.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yu-Pei Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-14 02:54:29	ID requested
⏵ 1	2025-08-03 16:19:01	announced

Publication List

10.3389/fphar.2025.1584233;
He Q, Chen YP, Wu C, Wu H, Li F, Li M, Chen F, Aloin protects against UVB-induced apoptosis by modulating integrated signaling pathways. Front Pharmacol, 16():1584233(2025) [pubmed]

10.3389/fphar.2025.1584233;

He Q, Chen YP, Wu C, Wu H, Li F, Li M, Chen F, Aloin protects against UVB-induced apoptosis by modulating integrated signaling pathways. Front Pharmacol, 16():1584233(2025) [pubmed]

Keyword List

submitter keyword: HaCaT cells, Aloin, UVB-induced apoptosis

submitter keyword: HaCaT cells, Aloin, UVB-induced apoptosis

Contact List

Yu-Pei Chen
contact affiliation	The School of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023, China
contact email	3399248132@qq.com
lab head
Yu-Pei Chen
contact affiliation	The School of Public Health and Medical Technology, Xiamen Medical College, Xiamen 361023
contact email	3399248132@qq.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD060808
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD060808

PRIDE project URI

Repository Record List

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