PXD060778

PXD060778 is an original dataset announced via ProteomeXchange.

Title	Proteome alterations in the human granulosa-like tumor cell line KGN after CRISPR/Cas9-based deletion of TRPV2
Description	Human ovarian granulosa cell tumors (GCT) express the cation channel transient receptor potential vanilloid 2 (TRPV2) to a large percentage (95%), as detected by analyzing a panel of 72 tissue samples. To examine its role, we turned to the GCT-derived cell line KGN. CRISPR/Cas9-based deletion of TRPV2 resulted in alterations in the proteome of these cells.
HostingRepository	PRIDE
AnnounceDate	2026-02-17
AnnouncementXML	Submission_2026-02-17_01:56:07.443.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Fröhlich
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-13 08:29:51	ID requested
⏵ 1	2026-02-17 01:56:08	announced

Eubler K, Jeevanandan SP, Caban KM, St, ö, ckl JB, Braun MB, Herrmann C, Schneider M, Kreitmair N, Scholz L, Mayr D, Renkawitz J, Welter H, M, ü, ller-Taubenberger A, Fr, ö, hlich T, Mayerhofer A, TRPV2 regulates cell fate in the human granulosa-like tumor cell line KGN: implications for granulosa cell tumors and cannabidiol. Cell Commun Signal, 24(1):(2026) [pubmed]

10.1186/s12964-026-02729-y;

submitter keyword: cannabidiol, granulosa cell tumors, KGN, cell death, TRPV2

Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München
contact email	frohlich@genzentrum.lmu.de
lab head
Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 81377 Munich
contact email	frohlich@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD060778

PRIDE project URI

• PRIDE
  1. PXD060778
     1. Label: PRIDE project
     2. Name: Proteome alterations in the human granulosa-like tumor cell line KGN after CRISPR/Cas9-based deletion of TRPV2