PXD060776

PXD060776 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	HDX-MS analysis of the DNA-mKu interaction and dynamics
Description	This project aims to decipher the DNA-protein interactions of the DNA end-binding protein mKu. In Mycobacterium tuberculosis and prokaryotes in general, Ku serves as the initiator of the non-homologous end-joining (NHEJ) DNA repair pathway. Using HDX-MS complemented with structural data, we investigate critical contacts at the DNA-protein interface and explore the dynamic behavior of the complex in solution.
HostingRepository	PRIDE
AnnounceDate	2026-01-19
AnnouncementXML	Submission_2026-01-18_17:26:31.720.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joydeep Baral
SpeciesList	scientific name: Mycobacterium tuberculosis H37Rv; NCBI TaxID: NEWT:83332;
ModificationList	No PTMs are included in the dataset
Instrument	SYNAPT G2-Si; Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-13 07:33:20	ID requested
⏵ 1	2026-01-18 17:26:32	announced

Publication List

10.1093/nar/gkaf1418;
Baral J, Ang CS, McMillan PJ, Shobhana K, Saini A, Hinde E, Das AK, Rouiller I, Bringing the ends together: cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis. Nucleic Acids Res, 54(1):(2026) [pubmed]

10.1093/nar/gkaf1418;

Baral J, Ang CS, McMillan PJ, Shobhana K, Saini A, Hinde E, Das AK, Rouiller I, Bringing the ends together: cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis. Nucleic Acids Res, 54(1):(2026) [pubmed]

Keyword List

submitter keyword: DNA synapsis,M.tuberculosis, NHEJ, Ku

submitter keyword: DNA synapsis,M.tuberculosis, NHEJ, Ku

Contact List

Isabelle Rouiller
contact affiliation	Professor Department of Biochemistry and Pharmacology, Bio21 institute University of Melbourne Australia
contact email	isabelle.rouiller@unimelb.edu.au
lab head
Joydeep Baral
contact affiliation	PhD
contact email	jbaral@student.unimelb.edu.au
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD060776
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD060776

PRIDE project URI

Repository Record List

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