PXD060751

PXD060751 is an original dataset announced via ProteomeXchange.

Title	DISC1 Protects Against Zika Virus Infection and Long-Term Neurological Damage Through AMPK-mTOR-Mediated Autophagy
Description	Disrupted in Schizophrenia 1 (DISC1) is essential for neuronal development and has been implicated in various psychiatric disorders. However, its role in Zika virus (ZIKV) infection, particularly in congenital Zika syndrome (CZS) and ZIKV-induced long-term neurodevelopmental defects, remains unexplored. In this study, we demonstrate that DISC1 suppresses ZIKV infection in human placental and neuroglia cells, as well as in murine macrophages. DISC1 also limits ZIKV dissemination from peripheral tissues to key organs of mice, including the uterus, testis, and brain, thereby reducing fetal abortion rates and intrauterine growth restriction. Notably, DISC1 is associated with long-term ZIKV effects, including memory loss, reduced anxiety and depression, declines in sociability and social novelty. Mechanistically, DISC1 activates autophagy by enhancing AMPKα phosphorylation and reducing mTOR phosphorylation, protecting against ZIKV infection. Additionally, DISC1 interacts with LC3 to further activate autophagy, partially contributing to inhibit ZIKV infection. In conclusion, DISC1 plays a critical factor in controlling ZIKV infection and mitigating CZS and ZIKV-induced neurocognitive decline.
HostingRepository	iProX
AnnounceDate	2025-02-13
AnnouncementXML	Submission_2025-02-12_20:34:09.395.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haolu Zha
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X; timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-12 20:32:38	ID requested
⏵ 1	2025-02-12 20:34:09	announced

Dataset with its publication pending

submitter keyword: ZIKV, DISC1, Autophagy, congenital Zika syndrome (CZS)

Huanle Luo
contact affiliation	Sun Yat-sen University
contact email	luohle@mail.sysu.edu.cn
lab head
Haolu Zha
contact affiliation	Sun Yat-sen University
contact email	zhahlu@mail2.sysu.edu.cn
dataset submitter

iProX dataset URI