PXD060750

PXD060750 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	GlycoAvatars: Bead-Coated Membrane Models for Studying the Cancer-Immune Cells Interactome
Description	Immature O-glycosylation, characterized by the Tn antigen expression rather than complex glycans, is prevalent in advanced solid tumors and promotes immune evasion. We developed GlycoAvatars, magnetic beads coated with plasma-membrane glycoproteins from glycoengineered cancer cell models, to identify cancer-immune cell interactomes. Through proteomics, we propose uncovered numerous membrane and intracellular proteins involved in glycan-mediated immune signaling, providing a novel high-throughput strategy for identifying potential relevant molecular nodes foreseeing therapeutic targets.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_18:12:37.327.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andreia Miranda
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-12 20:16:03	ID requested
⏵ 1	2026-09-06 18:12:38	announced

Publication List

10.1038/s42003-026-10274-0;
Miranda A, Relvas-Santos M, Louren, ç, o C, Ferreira E, Cunha DM, Palmeira C, Santos LL, Mattila PK, Ferreira JA, GlycoAvatars: bead-coated membrane models for studying the cancer-immune cells interactome. Commun Biol, 9(1):(2026) [pubmed]

10.1038/s42003-026-10274-0;

Miranda A, Relvas-Santos M, Louren, ç, o C, Ferreira E, Cunha DM, Palmeira C, Santos LL, Mattila PK, Ferreira JA, GlycoAvatars: bead-coated membrane models for studying the cancer-immune cells interactome. Commun Biol, 9(1):(2026) [pubmed]

Keyword List

submitter keyword: None

submitter keyword: None

Contact List

José Alexandre
contact affiliation	Research Center of IPO-Porto (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO-Porto) / Porto Comprehensive Cancer Center (P.ccc) Raquel Seruca, Porto, Portugal
contact email	jose.a.ferreira@ipoporto.min-saude.pt
lab head
Andreia Miranda
contact affiliation	IPO-Porto
contact email	i37220@ipoporto.min-saude.pt
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD060750
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD060750

PRIDE project URI

Repository Record List

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