PXD060743

PXD060743 is an original dataset announced via ProteomeXchange.

Title	Amniotic Fluid Reduces Liver Fibrosis By Attenuating Hepatic Stellate Cell Activation
Description	Chronic activation of hepatic stellate cells leads to irreversible liver fibrosis, and durable treatment options for liver fibrosis remain suboptimal, creating a critical clinical need. Amniotic fluid (AF) reduces inflammation and promotes tissue remodeling and regeneration when applied to cutaneous wounds and in models thereof. However, no prior studies have explored the anti-fibrotic benefits of AF in liver disease. Data from this study indicate that AF can repress liver fibrosis by reducing hepatic stellate cell myofibroblast activation. Thus, these findings lay the foundation for early-phase clinical trials investigating cell-free AF as a therapeutic treatment for liver fibrosis and as a bridging therapy for liver transplantation
HostingRepository	PRIDE
AnnounceDate	2025-07-14
AnnouncementXML	Submission_2025-07-13_16:20:09.617.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	William Russell
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-12 16:04:00	ID requested
⏵ 1	2025-07-13 16:20:10	announced

Bowen CM, Ditmars F, Liu N, Abril JM, Ajasin D, Russell WK, Stevenson HL, Eugenin EA, Fair JH, Fagg WS, Amniotic fluid reduces liver fibrosis by attenuating hepatic stellate cell activation. Stem Cells Transl Med, 14(7):(2025) [pubmed]

10.1093/stcltm/szaf026;

submitter keyword: Amniotic Fluid, LCMS

W. Samuel Fagg
contact affiliation	Assistant Professor, Surgery
contact email	wsfagg@utmb.edu
lab head
William Russell
contact affiliation	UTMB
contact email	wirussel@utmb.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD060743

PRIDE project URI

• PRIDE
  1. PXD060743
     1. Label: PRIDE project
     2. Name: Amniotic Fluid Reduces Liver Fibrosis By Attenuating Hepatic Stellate Cell Activation