PXD060737

PXD060737 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics of DAAO-TGTie2 aorta
Description	We pursued a chemogenetic approach to create an animal model of aortic aneurysm formation using a transgenic mouse line DAAO-TGTie2 that expresses yeast D-amino acid oxidase (DAAO) under control of the endothelial Tie2 promoter. In DAAO-TGTie2 mice, DAAO generates the reactive oxygen species hydrogen peroxide (H2O2) in endothelial cells only when provided with D-amino acids. When DAAO-TGTie2 mice are chronically fed D-alanine, the animals become hypertensive and develop abdominal but not thoracic aortic aneurysms. Generation of H2O2 in the endothelium leads to oxidative stress throughout the vascular wall.
HostingRepository	PRIDE
AnnounceDate	2025-02-18
AnnouncementXML	Submission_2025-02-18_08:08:14.783.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Michel
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-12 13:00:07	ID requested
⏵ 1	2025-02-18 08:08:15	announced

Dataset with its publication pending

submitter keyword: DAAO-TGTie2,aorta

Prof.Thomas Michel
contact affiliation	Cardiovascular Medicine Division, Brigham and Women’s Hospital, Boston, MA, USA
contact email	michel@hms.harvard.edu
lab head
Thomas Michel
contact affiliation	Professor, Brigham and Women's Hospital, Harvard Medical School
contact email	thomas_michel@hms.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD060737

PRIDE project URI

• PRIDE
  1. PXD060737
     1. Label: PRIDE project
     2. Name: Quantitative proteomics of DAAO-TGTie2 aorta