PXD060733 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nucleus Accumbens proteome disbalance in an adolescent mice model of schizophrenia and nicotine misuse comorbidity |
| Description | Considering the role of the nucleus accumbens (NAcc) as a common neurobiological substrate for the interplay between these psychiatric disorders, label-free proteomics was employed to identify NAcc deregulated proteins in male and female mice modeled to schizophrenia with a history of adolescent nicotine exposure. Phencyclidine was used to model schizophrenia and minipump infusions was used to model nicotine misuse. Enrichment Reactome pathway and protein–protein interaction analyses revealed the cytoskeleton and associated synaptic plasticity mechanisms, energy metabolism, and nervous system development, as affected in both females and males modeled to the comorbid condition. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-05-13 |
| AnnouncementXML | Submission_2025-05-13_06:07:43.439.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD060733 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Andres Rodriguez Vega |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-02-12 10:11:38 | ID requested | |
| ⏵ 1 | 2025-05-13 06:07:44 | announced | |
Publication List
| Souza TP, Rodr, í, guez-Vega A, Dutra-Tavares AC, Seme, ã, o KA, Filgueiras CC, Ribeiro-Carvalho A, Manh, ã, es AC, Abreu-Villa, ç, a Y, Nucleus Accumbens Proteome Disbalance in an Adolescent Mouse Model of Schizophrenia and Nicotine Misuse Comorbidity. Biomedicines, 13(4):(2025) [pubmed] |
| 10.3390/biomedicines13040901; |
| 10.6019/PXD060733; |
Keyword List
| ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
| submitter keyword: Psychiatric disorder |
| Nicotine addiction |
| Proteome |
| E-cigarette |
| Mass Spectrometry, Prodrome. |
Contact List
| Andres Rodriguez Vega |
|---|
| contact affiliation | 1. Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro (UERJ), Av. Prof. Manuel de Abreu 444, 5 andar – Vila Isabel, Rio de Janeiro, RJ, 20550-170, Brazil. |
| contact email | andresve22@gmail.com |
| lab head | |
| Andres Rodriguez Vega |
|---|
| contact affiliation | Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Centro Biomédico, Universidade do Estado do Rio de Janeiro |
| contact email | andresve22@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD060733 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060733
- Label: PRIDE project
- Name: Nucleus Accumbens proteome disbalance in an adolescent mice model of schizophrenia and nicotine misuse comorbidity
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