PXD060715

PXD060715 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Extracellular Matrix Proteome of Aging-Specific Fibrotic Niche Cells in Mouse Liver Tissue
Description	The extracellular matrix (ECM) is a complex network comprising hundreds of proteins, serving not only a structural role in shaping multicellular organisms but also participating in signaling processes. Moreover, the ECM exhibits high tissue specificity and undergoes significant alterations with aging progression. We analyzed the proteome of ECM produced by liver aging-specific fibrotic niche cells in old mice to obtain an age-related proteome profile. Our analysis revealed the identification of 714 quantifiable proteins, with 126 classified as matrisome proteins according to the matrisome database. Notably, proteins significantly upregulated in the ECM of liver aging-specific fibrotic niche cells indicated characteristics reminiscent of ECM formation (Eln, Mfap4, Lox, Tgfb2, Thbs2) and immune cell recruitment (Cxcl12), akin to those originating from fibrotic regions. Our findings suggest that this study may contribute to elucidating heightened fibrotic characteristics associated with the aging process.
HostingRepository	PRIDE
AnnounceDate	2025-02-13
AnnouncementXML	Submission_2025-02-12_21:07:44.738.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD060715
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Narae Park
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-12 03:39:58	ID requested
⏵ 1	2025-02-12 21:07:45	announced

Publication List

10.6019/PXD060715;

10.6019/PXD060715;

Keyword List

submitter keyword: LC-MS/MS based proteomics, tandem mass tag (TMT), senescence, extracellular matrix

submitter keyword: LC-MS/MS based proteomics, tandem mass tag (TMT), senescence, extracellular matrix

Contact List

Cheolju Lee
contact affiliation	Chemical and Biological Integrative Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea
contact email	clee270@kist.re.kr
lab head
Narae Park
contact affiliation	Korea institute of science and technology
contact email	nr_park@kist.re.kr
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD060715

PRIDE project URI

Repository Record List

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