PXD060699

PXD060699 is an original dataset announced via ProteomeXchange.

Title	Continuous and prolonged breastfeeding in wild Bornean orangutans verified with fecal proteomics
Description	Orangutans have a slow life history with one of the longest interbirth intervals and the lowest reported infant mortality rates among primates or even mammals. Breastfeeding is a key factor in their life history because it possibly promotes offspring health and increases maternal interbirth intervals. However, quantifying milk intake is difficult, and existing estimates for their weaning age are contradictory. In this study, we use fecal proteomics to predict the breastfeeding and weaning patterns in wild Bornean orangutans in Danum Valley, Sabah, Malaysia. Age changes in milk-specific proteins identified from 20 feces of five immature individuals revealed that the orangutans in Danum Valley consistently consumed milk for ≥6.5 years after birth, consistent with the behavioral evidence as having one of the longest breastfeeding periods in mammals. Milk intake was significantly correlated with higher levels of biological defense and probiotic bacterial proteins. Mothers were not pregnant with their next offspring during the breastfeeding period. These results indicate that a continuous and long breastfeeding period is a key component of the slow life history of orangutans and shows that fecal proteomics can be applied to a wide range of wild animal populations, with the potentials to uncover novel aspects of behavior and physiology.
HostingRepository	PRIDE
AnnounceDate	2026-03-19
AnnouncementXML	Submission_2026-03-19_02:54:23.458.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Takumi Tsutaya
SpeciesList	scientific name: Pongo pygmaeus morio; NCBI TaxID: NEWT:2753605;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-11 14:39:40	ID requested
⏵ 1	2026-03-19 02:54:23	announced

Dataset with its publication pending

submitter keyword: None

Takumi Tsutaya
contact affiliation	Research Center for Integrative Evolutionary Science, The Graduate University for Advanced Studies, Japan
contact email	tsutayatakumi@gmail.com
lab head
Takumi Tsutaya
contact affiliation	Graduate University for Advanced Studies, SOKENDAI
contact email	tsuta16@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD060699
     1. Label: PRIDE project
     2. Name: Continuous and prolonged breastfeeding in wild Bornean orangutans verified with fecal proteomics