PXD060691 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer |
Description | In the current investigation, we sought to characterize the implications of UCHL1 small molecule inhibition in both chemosensitive and chemoresistant HGSOC cells, generating an unprecedented understanding of the clinically relevant implications of targeting UCHL1. |
HostingRepository | PRIDE |
AnnounceDate | 2025-02-26 |
AnnouncementXML | Submission_2025-02-26_07:36:25.900.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nicholas DaSilva |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-02-11 10:08:41 | ID requested | |
⏵ 1 | 2025-02-26 07:36:26 | announced | |
Publication List
Keyword List
submitter keyword: Human, Ovarian Cancer, LC-MS, Small Molecule Inhibitor |
Contact List
Nicole James |
contact affiliation | Brown University |
contact email | nicole_james@brown.edu |
lab head | |
Nicholas DaSilva |
contact affiliation | Brown University
Director, Proteomics Core Facility
Deptartments of Molecular Biology, Cell Biology, and Biochemistry |
contact email | nicholas_dasilva@brown.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060691
- Label: PRIDE project
- Name: Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer