PXD060691

PXD060691 is an original dataset announced via ProteomeXchange.

Title	Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer
Description	In the current investigation, we sought to characterize the implications of UCHL1 small molecule inhibition in both chemosensitive and chemoresistant HGSOC cells, generating an unprecedented understanding of the clinically relevant implications of targeting UCHL1.
HostingRepository	PRIDE
AnnounceDate	2025-02-26
AnnouncementXML	Submission_2025-02-26_07:36:25.900.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nicholas DaSilva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-11 10:08:41	ID requested
⏵ 1	2025-02-26 07:36:26	announced

10.3389/FPHAR.2025.1547164;

submitter keyword: Human, Ovarian Cancer, LC-MS, Small Molecule Inhibitor

Nicole James
contact affiliation	Brown University
contact email	nicole_james@brown.edu
lab head
Nicholas DaSilva
contact affiliation	Brown University Director, Proteomics Core Facility Deptartments of Molecular Biology, Cell Biology, and Biochemistry
contact email	nicholas_dasilva@brown.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/02/PXD060691

PRIDE project URI

• PRIDE
  1. PXD060691
     1. Label: PRIDE project
     2. Name: Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer