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PXD060691

PXD060691 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSmall molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer
DescriptionIn the current investigation, we sought to characterize the implications of UCHL1 small molecule inhibition in both chemosensitive and chemoresistant HGSOC cells, generating an unprecedented understanding of the clinically relevant implications of targeting UCHL1.
HostingRepositoryPRIDE
AnnounceDate2025-02-26
AnnouncementXMLSubmission_2025-02-26_07:36:25.900.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterNicholas DaSilva
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-02-11 10:08:41ID requested
12025-02-26 07:36:26announced
Publication List
10.3389/FPHAR.2025.1547164;
Keyword List
submitter keyword: Human, Ovarian Cancer, LC-MS, Small Molecule Inhibitor
Contact List
Nicole James
contact affiliationBrown University
contact emailnicole_james@brown.edu
lab head
Nicholas DaSilva
contact affiliationBrown University Director, Proteomics Core Facility Deptartments of Molecular Biology, Cell Biology, and Biochemistry
contact emailnicholas_dasilva@brown.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
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