PXD060651

PXD060651 is an original dataset announced via ProteomeXchange.

Title	Identification of proteins bound with RPA194 at rRNA loci in primary versus metastatic breast cancer cells
Description	The nucleolus, the site of ribosome biogenesis, serves as a central hub for sensing and responding to cellular stress and plays a crucial role in this process; furthermore, emerging evidence highlights the potential role of ribosome biogenesis in driving metastasis. A combined approach of chromatin immunoprecipitation (ChIP) with mass spectrometry identified unique binding partners of RPA194 (the major subunit of RNA polI) in metastatic versus non-metastatic breast cancer cells.
HostingRepository	PRIDE
AnnounceDate	2025-07-27
AnnouncementXML	Submission_2025-07-27_10:29:56.555.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD060651
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Brandon Metge
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-10 13:45:53	ID requested
⏵ 1	2025-07-27 10:29:56	announced

10.6019/PXD060651;

submitter keyword: breast cancer, RPA194,ChIP, metastasis

Dr. Lalita Samant
contact affiliation	University of Alabama at Birmingham, Department of Pathology, Division MCP, O'Neal Comprehensive Cancer Center
contact email	lalitasamant@uabmc.edu
lab head
Brandon Metge
contact affiliation	University of Alabama at Birmingham
contact email	brandonmetge@uabmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD060651

PRIDE project URI

• PRIDE
  1. PXD060651
     1. Label: PRIDE project
     2. Name: Identification of proteins bound with RPA194 at rRNA loci in primary versus metastatic breast cancer cells