PXD060537

PXD060537 is an original dataset announced via ProteomeXchange.

Title	Integrated Proteomics and Metabolomics Profiling unveils biomarkers and immune characteristics for Pelvic Lymph Node Metastasis in Cervical Cancer
Description	Pelvic lymph node metastasis (PLNM) significantly affects the prognosis of cervical cancer (CC). However, current imaging examinations and serum squamous cell carcinoma antigen (SCCA) testing are inadequate for assessing the pelvic lymph node status in CC. To identify accurate noninvasive biomarkers for predicting PLNM for minimizing unnecessary postoperative lymphadenectomy and its associated complications, we performed a comprehensive proteomic and metabolomic analysis of plasma from 124 patients with CC, along with a proteomic analysis of 52 paired tissue samples. Through machine learning methods, we identified potential plasma biomarkers (TTR, MASP2, APOD, and 7α-Hydroxy-cholestene-3-one) and constructed a diagnostic model. In the validation cohort, the diagnostic model combined with SCCA exhibited a higher sensitivity (72.4%) than SCCA (64.3%) and imaging examination (14.3%). The plasma protein biomarkers were consistently validated in paired tissue samples. Additionally, immune infiltration analysis demonstrated that CD4 and CD8 T cells were highly infiltrated in the PLNM group, suggesting a potentially enhanced response to immunotherapy. Here, we established a biomarker panel for PLNM and highlighted the altered immune characteristics associated with PLNM, offering valuable insights for the development of immunotherapy strategies for patients with PLNM.
HostingRepository	iProX
AnnounceDate	2025-02-06
AnnouncementXML	Submission_2025-02-05_20:00:57.017.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Zhu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-05 20:00:43	ID requested
⏵ 1	2025-02-05 20:00:57	announced

Dataset with its publication pending

submitter keyword: cervical cancer, pelvic lymph node metastasis, biomarker, metabolomics, proteomics

Wei Zhu
contact affiliation	Hangzhou Institute of Medicine, Chinese Academy of Sciences
contact email	zhuwei@him.cas.cn
lab head
Wei Zhu
contact affiliation	Hangzhou Institute of Medicine, Chinese Academy of Sciences
contact email	zhuwei@him.cas.cn
dataset submitter

iProX dataset URI