PXD060501
PXD060501 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis of Bone Marrow Cells from ADO2 Mouse |
| Description | This project aims to investigate N-linked glycosylation modifications in bone marrow cells (BMCs) of an autosomal dominant osteopetrosis type 2 (ADO2) mouse model carrying the Clcn7 (r284w) mutation. Using LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis, we identified significant alterations in the N-glycosylation landscape of ADO2 BMCs compared to wild-type (WT) controls. These findings provide insights into the role of glycosylation in ADO2 pathogenesis, particularly in mononuclear phagocytes. |
| HostingRepository | iProX |
| AnnounceDate | 2025-02-05 |
| AnnouncementXML | Submission_2025-04-24_19:05:01.013.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Minglin Ou |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-02-04 22:46:12 | ID requested | |
| 1 | 2025-02-04 22:46:29 | announced | |
| ⏵ 2 | 2025-04-24 19:05:01 | announced | 2025-04-25: Add Publication. |
Publication List
Keyword List
| submitter keyword: Osteopetrosis Type 2, N-Glycosylation Proteomics, Bone Marrow Cells |
Contact List
| Minglin Ou | |
|---|---|
| contact affiliation | Guilin Medical University |
| contact email | minglinou@glmc.edu.cn |
| lab head | |
| Minglin Ou | |
| contact affiliation | Guilin Medical University |
| contact email | minglinou@glmc.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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