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PXD060501

PXD060501 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis of Bone Marrow Cells from ADO2 Mouse
DescriptionThis project aims to investigate N-linked glycosylation modifications in bone marrow cells (BMCs) of an autosomal dominant osteopetrosis type 2 (ADO2) mouse model carrying the Clcn7 (r284w) mutation. Using LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis, we identified significant alterations in the N-glycosylation landscape of ADO2 BMCs compared to wild-type (WT) controls. These findings provide insights into the role of glycosylation in ADO2 pathogenesis, particularly in mononuclear phagocytes.
HostingRepositoryiProX
AnnounceDate2025-02-05
AnnouncementXMLSubmission_2025-04-24_19:05:01.013.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMinglin Ou
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-02-04 22:46:12ID requested
12025-02-04 22:46:29announced
22025-04-24 19:05:01announced2025-04-25: Add Publication.
Publication List
Sha Y, Huang L, Zhang L, Hou X, Mo C, Pan C, Chen G, Luo S, Ou M, SUGAR-seq reveals the transcriptome and N-linked glycosylation landscape of mononuclear phagocytes at single-cell resolution in a mouse model of autosomal dominant osteopetrosis type 2. BMC Biol, 23(1):91(2025) [pubmed]
Keyword List
submitter keyword: Osteopetrosis Type 2, N-Glycosylation Proteomics, Bone Marrow Cells
Contact List
Minglin Ou
contact affiliationGuilin Medical University
contact emailminglinou@glmc.edu.cn
lab head
Minglin Ou
contact affiliationGuilin Medical University
contact emailminglinou@glmc.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI