PXD060501
PXD060501 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis of Bone Marrow Cells from ADO2 Mouse |
Description | This project aims to investigate N-linked glycosylation modifications in bone marrow cells (BMCs) of an autosomal dominant osteopetrosis type 2 (ADO2) mouse model carrying the Clcn7 (r284w) mutation. Using LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis, we identified significant alterations in the N-glycosylation landscape of ADO2 BMCs compared to wild-type (WT) controls. These findings provide insights into the role of glycosylation in ADO2 pathogenesis, particularly in mononuclear phagocytes. |
HostingRepository | iProX |
AnnounceDate | 2025-02-05 |
AnnouncementXML | Submission_2025-04-24_19:05:01.013.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Minglin Ou |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-02-04 22:46:12 | ID requested | |
1 | 2025-02-04 22:46:29 | announced | |
⏵ 2 | 2025-04-24 19:05:01 | announced | 2025-04-25: Add Publication. |
Publication List
Sha Y, Huang L, Zhang L, Hou X, Mo C, Pan C, Chen G, Luo S, Ou M, SUGAR-seq reveals the transcriptome and N-linked glycosylation landscape of mononuclear phagocytes at single-cell resolution in a mouse model of autosomal dominant osteopetrosis type 2. BMC Biol, 23(1):91(2025) [pubmed] |
Keyword List
submitter keyword: Osteopetrosis Type 2, N-Glycosylation Proteomics, Bone Marrow Cells |
Contact List
Minglin Ou | |
---|---|
contact affiliation | Guilin Medical University |
contact email | minglinou@glmc.edu.cn |
lab head | |
Minglin Ou | |
contact affiliation | Guilin Medical University |
contact email | minglinou@glmc.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |