PXD060501

PXD060501 is an original dataset announced via ProteomeXchange.

Title	LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis of Bone Marrow Cells from ADO2 Mouse
Description	This project aims to investigate N-linked glycosylation modifications in bone marrow cells (BMCs) of an autosomal dominant osteopetrosis type 2 (ADO2) mouse model carrying the Clcn7 (r284w) mutation. Using LC-MS/MS-based 4D Label-Free N-Glycosylation Proteomics Analysis, we identified significant alterations in the N-glycosylation landscape of ADO2 BMCs compared to wild-type (WT) controls. These findings provide insights into the role of glycosylation in ADO2 pathogenesis, particularly in mononuclear phagocytes.
HostingRepository	iProX
AnnounceDate	2025-02-05
AnnouncementXML	Submission_2025-04-24_19:05:01.013.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Minglin Ou
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-04 22:46:12	ID requested
1	2025-02-04 22:46:29	announced
⏵ 2	2025-04-24 19:05:01	announced	2025-04-25: Add Publication.

Sha Y, Huang L, Zhang L, Hou X, Mo C, Pan C, Chen G, Luo S, Ou M, SUGAR-seq reveals the transcriptome and N-linked glycosylation landscape of mononuclear phagocytes at single-cell resolution in a mouse model of autosomal dominant osteopetrosis type 2. BMC Biol, 23(1):91(2025) [pubmed]

submitter keyword: Osteopetrosis Type 2, N-Glycosylation Proteomics, Bone Marrow Cells

Minglin Ou
contact affiliation	Guilin Medical University
contact email	minglinou@glmc.edu.cn
lab head
Minglin Ou
contact affiliation	Guilin Medical University
contact email	minglinou@glmc.edu.cn
dataset submitter

iProX dataset URI