⮝ Full datasets listing
PXD060482
PXD060482 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics reveals spatial and molecular heterogeneities in advanced atherosclerotic carotid artery plaques |
| Description | Atherosclerotic plaque rupture is a major cause of cerebrovascular events, yet the molecular determinants underlying vulnerability-related plaque morphology, including fibrous cap thickness, remain incompletely defined. Using histomorphology-guided spatial proteomics, here we delineate molecular programmes associated with plaque cap phenotype across discrete plaque subregions. Across 112 carotid endarterectomy specimens, differences between thin-cap and thick-cap plaques were predominantly localised to the necrotic core and fibrous cap. These differences were enriched for processes related to inflammation, lipid handling, extracellular matrix remodelling, and ossification/calcification, and supported the presence of proteome-based plaque subtypes. PCSK9 was among the proteins most strongly associated with thin-cap plaques. Consistently, an in vitro model of necrotic core-like oxidative and inflammatory stress increased PCSK9 secretion in primary vascular smooth muscle cells. Together, these findings localise molecular programmes associated with cap phenotype to plaque compartments and provide a framework for spatially informed biomarker discovery in advanced carotid atherosclerosis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-04-30 |
| AnnouncementXML | Submission_2026-04-30_00:11:50.152.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | mario oroshi |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Ultra; Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-02-04 14:45:57 | ID requested | |
| ⏵ 1 | 2026-04-30 00:11:50 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: atherosclerosis, subregions, smooth muscle cells, DatasetType:Proteomics |
Contact List
| Matthias Mann | |
|---|---|
| contact affiliation | Proteomics and Signal Transduction Max Planck Institute of Biochemistry Am Klopferspitz 18 D-82152 Martinsried |
| contact email | mmann@biochem.mpg.de |
| lab head | |
| mario oroshi | |
| contact affiliation | MPI |
| contact email | oroshi@biochem.mpg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v09/MSV000097042/ |
