PXD060469

PXD060469 is an original dataset announced via ProteomeXchange.

Title	Elucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction
Description	PTEN-WT and PTEN-4A models generation using Rosetta restrained with XL-MS crosslink distance restraints. Two major conformations of each protein were modeled
HostingRepository	PRIDE
AnnounceDate	2025-06-09
AnnouncementXML	Submission_2025-06-09_10:19:51.331.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD060469
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Belinda Willard
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-04 08:14:53	ID requested
⏵ 1	2025-06-09 10:19:51	announced

10.6019/PXD060469;

submitter keyword: molecular dynamics, molecular modeling, molecular biology, conformational change, RaSP stability prediction, crosslinking mass spectrometry (XL-MS), AlphaMissense, clinical mutation, integrative structural modeling,Phosphatase and tensin homolog (PTEN)

Jennifer E Dawson
contact affiliation	Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, United States.
contact email	DAWSONJ8@ccf.org
lab head
Belinda Willard
contact affiliation	Cleveland Clinic
contact email	willarb@ccf.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD060469

PRIDE project URI

• PRIDE
  1. PXD060469
     1. Label: PRIDE project
     2. Name: Elucidating PTEN Conformational Dynamics and Phosphatase Regulation via Integrative Modeling and Mutation Prediction