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PXD060461

PXD060461 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAssessing Customized Multivalent Chemokine-Binding Peptide Treatment in a Murine Model of Coxsackievirus B3 Infection
DescriptionThis study investigates the therapeutic potential of BK1.3, a synthetic Evasin-derived peptide, in a murine model of Coxsackievirus B3 (CVB3)-induced viral myocarditis. Myocarditis, an inflammatory disease of the heart muscle, is often triggered by viral infections and driven by excessive immune cell infiltration, mediated by chemokines. BK1.3 selectively targets and inhibits key CC chemokines involved in inflammation, potentially mitigating immune-mediated cardiac damage while preserving essential host defense mechanisms. Beyond its impact on cardiac inflammation, CVB3 infection induces systemic effects, including metabolic disturbances and liver dysfunction. The liver plays a critical role in regulating energy homeostasis and immune responses during infection, making it essential to understand how CVB3 alters hepatic metabolism and whether BK1.3 treatment influences these changes. To explore the metabolic adaptations of the liver during CVB3 infection and under BK1.3 treatment, we conducted a comprehensive proteomic analysis of liver tissue. Our goal was to assess infection-induced changes in protein expression related to metabolism, as well as to determine the extent to which BK1.3 modulates these processes. To interpret the functional implications of the observed proteomic changes, we applied HepatoKin1, a computational liver metabolism model, integrating protein abundance data to simulate metabolic pathway activity. This approach provided insights into how viral infection reprograms hepatic metabolism and how targeted chemokine inhibition may affect these adapatations. The dataset offers a valuable resource for understanding systemic metabolic responses in murine viral myocarditis and evaluating the potential benefits of chemokine-targeted therapy.
HostingRepositoryPRIDE
AnnounceDate2025-05-07
AnnouncementXMLSubmission_2025-05-07_08:38:48.005.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnja Freiwald
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Coxsackievirus; NCBI TaxID: NCBITaxon:12066;
ModificationListiodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-02-04 06:23:59ID requested
12025-05-07 08:38:48announced
Publication List
Kelm N, Kespohl M, Smagurauskaite G, Vales S, Karuppanan K, Mburu P, Thiele A, Pinkert S, Bukur T, M, ü, lleder M, Berndt N, Klingel K, Gaida MM, Bhattacharya S, Beling A, Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis. Basic Res Cardiol, 120(2):393-422(2025) [pubmed]
10.1007/s00395-025-01098-w;
Keyword List
submitter keyword: infection, inflammation, liver metabolism, Evasin, chemokines, coxsackievirus B3
Contact List
Prof. Dr. med. Antje Beling
contact affiliationCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Biochemistry, 10117 Berlin, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Berlin, 10117 Berlin, Germany
contact emailantje.beling@charite.de
lab head
Anja Freiwald
contact affiliationCharité
contact emailanja.freiwald@charite.de
dataset submitter
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Dataset FTP location
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