PXD060461

PXD060461 is an original dataset announced via ProteomeXchange.

Title	Assessing Customized Multivalent Chemokine-Binding Peptide Treatment in a Murine Model of Coxsackievirus B3 Infection
Description	This study investigates the therapeutic potential of BK1.3, a synthetic Evasin-derived peptide, in a murine model of Coxsackievirus B3 (CVB3)-induced viral myocarditis. Myocarditis, an inflammatory disease of the heart muscle, is often triggered by viral infections and driven by excessive immune cell infiltration, mediated by chemokines. BK1.3 selectively targets and inhibits key CC chemokines involved in inflammation, potentially mitigating immune-mediated cardiac damage while preserving essential host defense mechanisms. Beyond its impact on cardiac inflammation, CVB3 infection induces systemic effects, including metabolic disturbances and liver dysfunction. The liver plays a critical role in regulating energy homeostasis and immune responses during infection, making it essential to understand how CVB3 alters hepatic metabolism and whether BK1.3 treatment influences these changes. To explore the metabolic adaptations of the liver during CVB3 infection and under BK1.3 treatment, we conducted a comprehensive proteomic analysis of liver tissue. Our goal was to assess infection-induced changes in protein expression related to metabolism, as well as to determine the extent to which BK1.3 modulates these processes. To interpret the functional implications of the observed proteomic changes, we applied HepatoKin1, a computational liver metabolism model, integrating protein abundance data to simulate metabolic pathway activity. This approach provided insights into how viral infection reprograms hepatic metabolism and how targeted chemokine inhibition may affect these adapatations. The dataset offers a valuable resource for understanding systemic metabolic responses in murine viral myocarditis and evaluating the potential benefits of chemokine-targeted therapy.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_08:38:48.005.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anja Freiwald
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Coxsackievirus; NCBI TaxID: NCBITaxon:12066;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-02-04 06:23:59	ID requested
⏵ 1	2025-05-07 08:38:48	announced

Kelm N, Kespohl M, Smagurauskaite G, Vales S, Karuppanan K, Mburu P, Thiele A, Pinkert S, Bukur T, M, ü, lleder M, Berndt N, Klingel K, Gaida MM, Bhattacharya S, Beling A, Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis. Basic Res Cardiol, 120(2):393-422(2025) [pubmed]

10.1007/s00395-025-01098-w;

submitter keyword: infection, inflammation, liver metabolism, Evasin, chemokines, coxsackievirus B3

Prof. Dr. med. Antje Beling
contact affiliation	Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Biochemistry, 10117 Berlin, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Berlin, 10117 Berlin, Germany
contact email	antje.beling@charite.de
lab head
Anja Freiwald
contact affiliation	Charité
contact email	anja.freiwald@charite.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD060461

PRIDE project URI

• PRIDE
  1. PXD060461
     1. Label: PRIDE project
     2. Name: Assessing Customized Multivalent Chemokine-Binding Peptide Treatment in a Murine Model of Coxsackievirus B3 Infection