PXD060369

PXD060369 is an original dataset announced via ProteomeXchange.

Title	Generation of drug-tolerant cells by lncRNAs downstream of osmotic stress
Description	Environmental cues within the tumor microenvironment (TME) affect tumor heterogeneity and plasticity, ultimately influencing therapy responses. Recent studies have shown that cancer stem cell niches are located near blood vessels and thus may be exposed to abrupt changes in the osmotic conditions. Here, we investigated how osmotic stress induced by the TME contributes to the generation of drug-tolerant persister cells in melanoma. Our research provide evidence that osmotic stress promotes cancer cell adaptation and reprogramming toward an NCSC-like state, with long non-coding RNAs (lncRNAs) emerging as likely (and druggable) mediators of this mechanical stress, converting osmotic gradients into specific molecular signals. Critically, we have identified MOMO (Melanoma Osmosis MediatOr) as a novel transcript deregulated upon osmotic stress and associated with poor prognosis in melanoma. Our findings suggest that MOMO plays a crucial role in osmotic stress-induced adaptive reprogramming in melanoma by acting as a key player in the DNA Damage Response, thereby altering tumor composition and impacting therapy outcomes.
HostingRepository	PRIDE
AnnounceDate	2026-05-31
AnnouncementXML	Submission_2026-05-31_02:16:33.570.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	alessandro cuomo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-30 07:28:01	ID requested
⏵ 1	2026-05-31 02:16:34	announced

Dataset with its publication pending

submitter keyword: IncRNAs,CANCER, DDA

Eleonora Leucci
contact affiliation	Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium; Department of Oncology and Hematology-Oncology, University of Milan, Milan, 20122 Italy
contact email	eleonora.leucci@kuleuven.be
lab head
alessandro cuomo
contact affiliation	IEO
contact email	alessandro.cuomo@ieo.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD060369

PRIDE project URI

• PRIDE
  1. PXD060369
     1. Label: PRIDE project
     2. Name: Generation of drug-tolerant cells by lncRNAs downstream of osmotic stress