⮝ Full datasets listing
PXD060345
PXD060345 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chemical Digestion-Assisted Proteomic Analysis of Extracellular Matrix Profile of Human Periodontal Ligament |
| Description | The extracellular matrix (ECM) plays a crucial role in tissue structure and function and serves as an integral component of diverse biological systems. However, the comprehensive characterization of ECM components is challenging because of the insoluble nature of highly cross-linked and glycosylated ECM proteins. This study introduces a chemical digestion-assisted proteomic approach to overcome challenges in ECM profiling, offering an in-depth analysis of the human periodontal ligament (PDL), a tissue critical for oral function and regeneration. Furthermore, we investigated alterations in the ECM composition of cultured PDL-derived cells to provide insights relevant to tissue engineering applications. Our protocol combined chemical digestion and deglycosylation to enhance the identification of ECM proteins. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-07-12 |
| AnnouncementXML | Submission_2026-07-11_08:00:05.019.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Masaru Kaku |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; monohydroxylated proline; monohydroxylated lysine; 2-pyrrolidone-5-carboxylic acid (Gln); 2-pyrrolidone-5-carboxylic acid (Glu); alpha-amino acetylated residue |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-29 17:45:43 | ID requested | |
| ⏵ 1 | 2026-07-11 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: human, periodontal ligament, extracellular matrix, hydroxylamine |
Contact List
| Masaru Kaku | |
|---|---|
| lab head | |
| Masaru Kaku | |
| contact affiliation | Niigata University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003579/ |
