PXD060285

PXD060285 is an original dataset announced via ProteomeXchange.

Title	Impact of FGF-2 and FGF-2 containing cell culture supernatants on the intracellular protein composition of ReNcell derived neuron
Description	FGF-2 is an important protein involved in a vast number of molecular pathways and a number of cellular functions including glial cell differentiation and response to axon injury. This protein was found to be present significantly in supernatants of female derived murine oligodendrocyte progenitor cells (OPC) that have been maintained under hyperoxic conditions. Therefore, this protein might be important in protecting the brain against oxidative stress. Functional assays on neuronal cells in the presence of FGF-2 or OPC culture supernatants were performed and findings related to the impact of the treatment conditions on the intracellular protein response of ReNcell derived neurons were reported.
HostingRepository	PRIDE
AnnounceDate	2025-09-29
AnnouncementXML	Submission_2025-09-28_17:15:13.101.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elke Hammer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-28 08:27:47	ID requested
⏵ 1	2025-09-28 17:15:13	announced

10.1002/jex2.70082;

Sunny DE, Hammer E, Michalik S, V, ö, lker U, Heckmann M, Sex-Specific Differences in the Secretome of Oligodendrocyte Progenitor Cells Post Hyperoxic Stress. J Extracell Biol, 4(9):e70082(2025) [pubmed]

submitter keyword: Human neural progenitor cell line, ReNcell VM, OPC cell culture supernatant, FGF-2, secretome LC-MS/MS

Dr. Elke Hammer
contact affiliation	Dr. Elke Hammer Universitätsmedizin Greifswald Interfakultäres Institut für Genetik und Funktionelle Genomforschung Abteilung für Funktionelle Genomforschung Felix-Hausdorff-Straße 8 17487 Greifswald Germany
contact email	hammer@uni-greifswal.de
lab head
Elke Hammer
contact affiliation	Dept. of Functional Genomics
contact email	hammer@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD060285

PRIDE project URI

• PRIDE
  1. PXD060285
     1. Label: PRIDE project
     2. Name: Impact of FGF-2 and FGF-2 containing cell culture supernatants on the intracellular protein composition of ReNcell derived neuron