PXD060215

PXD060215 is an original dataset announced via ProteomeXchange.

Title	Dietary carbohydrates alter immune-modulatory functionalities and DNA inversions in Bacteroides thetaiotaomicron
Description	The environment of gut bacteria is extremely dynamic. Environmental conditions were shown to affect microbial composition, however, their effects on bacterial functionality (e.g., immune-modulation activity) are mostly overlooked. Distinct strains of the same species, and even the same bacterial strain, may have different effects on the immune system depending on their growth environment. Therefore, studying the functionality of strains, under different conditions, is crucial. We analyzed functional alterations in the gut symbiont Bacteroides thetaiotaomicron (B. theta) under different diets in humans, under sugar consumption in mice, and in response to 190 different carbon sources in vitro. Dietary alterations affected the orientation of phase variable promoters in B. theta in humans, in vivo and in vitro and altered B. theta’s proteome and immune-modulatory functionality. Studying the effects of dietary components on the immune-modulatory functionalities of key members of the gut microbiota will allow tailored dietary recommendations to patients.
HostingRepository	PRIDE
AnnounceDate	2025-05-04
AnnouncementXML	Submission_2025-05-04_07:21:35.323.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Ziv
SpeciesList	scientific name: Bacteroides thetaiotaomicron CAG:40; NCBI TaxID: 1263054;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-26 11:07:18	ID requested
⏵ 1	2025-05-04 07:21:35	announced

Dataset with its publication pending

submitter keyword: immune-modulator, Bacteroides, Dietary carbohydrates

Naama Geva-Zatorsky
contact affiliation	Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine and Research Institute, Rappaport Technion Integrated Cancer Center (RTICC), Technion-Israel Institute of Technology, Israel
contact email	naamagvz@gmail.com
lab head
Tamar Ziv
contact affiliation	Technion
contact email	tamarz@technion.ac.il
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD060215
     1. Label: PRIDE project
     2. Name: Dietary carbohydrates alter immune-modulatory functionalities and DNA inversions in Bacteroides thetaiotaomicron