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PXD060212

PXD060212 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCAV2-expressing Nerves induce Metabolic Switch toward Mitochondrial Oxidative Phosphorylation to Promote Cancer Stemness
DescriptionCancer cells and the nervous system engage in a dynamic interplay, significantly influencing initiation and progression in head and neck squamous cell carcinoma (HNSCC). Our findings highlight that cancer cells drive an increase in caveolin-2 (Cav2) expression within trigeminal ganglia and associated neural fibers in the tumor milieu, fostering a reciprocal attractant relationship between tumor cells and nerves. Notably, the knockout of Cav2, either globally or specifically in sensory neurons or glial cells, markedly attenuates the growth of orthotopically implanted tongue tumors. Moreover, Cav2-expressing nerves are implicated in shifting cancer cell metabolism towards mitochondrial oxidative phosphorylation, a process involved in maintenance of cancer stem cells (CSCs). Our results also demonstrate that Cav2-expressing nerves confer stemness properties to cancer cells. Disruption of Cav2 expression, both globally and in specific neural cell types, impedes tumorigenesis and progression in a 4-NQO-induced HNSCC mouse model. This interplay between cancer cells, neurons, and glial cells unveils a mechanism through which tumor-associated nerves contribute to cancer stemness via metabolic reprogramming, presenting a novel avenue for anticancer therapy.
HostingRepositoryPRIDE
AnnounceDate2025-02-04
AnnouncementXMLSubmission_2025-02-04_06:18:44.841.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterZe Zhang
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-01-26 00:31:05ID requested
12025-02-04 06:18:45announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Cav2
cancer neuroscience
perineural invasion
oxidative phosphorylation;cancer stemness
Contact List
Zhang ze
contact affiliationTianjin Medical University Cancer Institute and Hospital
contact emailzhangze@tmu.edu.cn
lab head
Ze Zhang
contact affiliationzhangze@tmu.edu.cn
contact emailzhangze@tmu.edu.cn
dataset submitter
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Dataset FTP location
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