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PXD060097
PXD060097 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A disintegrin-like and metalloproteinase domain with thrombospondin motif 18 (ADAMTS18) cleaves fibronectin and regulates its fibrillogenesis |
| Description | Remodelling of the extracellular matrix (ECM) plays a crucial role in the development, maintenance and repair of all tissues. Therefore, identifying the regulators of this process is essential for understanding the mechanisms of tissue homeostasis. Among these regulators, A disintegrin and metalloproteinase with a thrombospondin motif 18 (ADAMTS18) has been implicated in fibronectin (FN) matrix regulation. However, how ADAMTS18 influences endothelial specific functions and its role in ECM maturation, particularly in the regulation of FN fibrillogenesis, remains unclear. In this study, using mass spectrometry, we identified two sites in FN that are proteolytically cleaved by ADAMTS18, including a cleavage site in the linker FN-I5-6. Cleavage at this site generated FN molecules lacking the N-terminal FN-I1-5 (29kDa) fragment that is known to be essential for FN fibrillogenesis. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2026-02-10 |
| AnnouncementXML | Submission_2026-02-10_19:51:24.196.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Mikko Gynther |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | Phospho; Deamidated; Carbamidomethyl; Oxidation |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-22 23:42:51 | ID requested | |
| ⏵ 1 | 2026-02-10 19:51:25 | announced |
Publication List
| Barbiera M, Gynther M, Terasaki T, Jauhiainen S, Laakkonen JP, Jeltsch M, Yl, รค, -Herttuala S, Laham-Karam N, A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) cleaves fibronectin and negatively regulates its fibrillogenesis. J Biol Chem, 301(12):110844(2025) [pubmed] |
Keyword List
| submitter keyword: ADAMTS18, Fibronectin, extracellular matrix remodelling |
Contact List
| Mikko Gynther | |
|---|---|
| contact affiliation | University of Eastern Finland |
| contact email | mikko.gynther@uef.fi |
| lab head | |
| Mikko Gynther | |
| contact affiliation | University of Eastern Finland |
| contact email | mikko.gynther@uef.fi |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
