PXD060091

PXD060091 is an original dataset announced via ProteomeXchange.

Title	Cholangiocarcinoma PDHA1 Succinylation Suppresses Macrophage Antigen Presentation via α-KG Accumulation
Description	Cholangiocarcinoma, ranking as the second most prevalent primary hepatic malignancy following hepatocellular carcinoma, is distinguished by its aggressive invasiveness and grim prognosis. Over the past decade, chemotherapy has persisted as the standard first-line treatment for cholangiocarcinoma; However, the outcomes in terms of efficacy and patient survival have remained disappointingly suboptimal due to the emergence of chemotherapy resistance issues. Thus, a newer and deeper understanding of pathways to regulate cholangiocarcinoma progression and sentisize chemotherapy therapy is needed. Metabolic reprogramming is a hallmark of cancer, intricately linked to post-translational modifications . The critical role of novel acyl modifications in tumorigenesis has garnered widespread attention in recent years . Succinylation, a new post-translational modification occurring on lysine residues, is involved in many core energy metabolic pathways, including the tricarboxylic acid cycle and glucose metabolism, and plays a role in regulating the progression of various tumors. In this study, from the perspective of succinylation modification, we explore a novel mechanism of cholangiocarcinoma progression and proposed a new direction for sensitized chemotherapy treatment.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_06:29:55.764.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ning Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	succinylated residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-22 18:52:03	ID requested
⏵ 1	2025-05-07 06:29:56	announced

Zhang N, Sun L, Zhou S, Ji C, Cui T, Chu Q, Ye J, Liang S, Ma K, Liu Y, Li X, Guo X, Zhang W, Gu X, Cheng C, Zha Q, Tao S, Zhang Y, Chu J, Wu C, Zhang Y, Wang J, Liu Y, Liu L, Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation. Nat Commun, 16(1):3177(2025) [pubmed]

10.1038/s41467-025-58429-7;

submitter keyword: metabolism, PDHA1, macrophages,Cholangiocarcinoma

Ning Zhang
contact affiliation	Department of General Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei, Anhui, 230001, China. Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, Anhui, 230001, China.
contact email	zhangning6563@163.com
lab head
Ning Zhang
contact affiliation	The First Affiliated Hospital of Harbin Medical University
contact email	zhangning6563@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD060091

PRIDE project URI

• PRIDE
  1. PXD060091
     1. Label: PRIDE project
     2. Name: Cholangiocarcinoma PDHA1 Succinylation Suppresses Macrophage Antigen Presentation via α-KG Accumulation