PXD060076 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ultrafast proteomics revealed everolimus-induced inhibition of 20S proteasome subunit |
| Description | In this study, we compare the proteomic responses of three cell lines (A549, HCT116, and MCF-7) to treatment with three antitumor drugs (bortezomib, everolimus, and lonidamine), with a particular focus on the effects on the ubiquitin-proteasome system. Liquid chromatography–mass spectrometry (LC-MS) experiments for cellular samples were conducted using an Orbitrap Q Exactive HF mass spectrometer, and the data were analyzed utilizing the DirectMS1 method. Cellular samples treated with bortezomib and lonidamine served as negative and positive controls, respectively, while the samples treated with everolimus constituted the primary subject of investigation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-20 |
| AnnouncementXML | Submission_2026-07-19_22:56:12.547.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Elizaveta Kazakova |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-22 12:52:52 | ID requested | |
| ⏵ 1 | 2026-07-19 22:56:13 | announced | |
Publication List
Keyword List
| submitter keyword: lonidamine,DirectMS1, LC-MS, bortezomib, everolimus, Chemical proteomics, cell line |
Contact List
| Mikhail V. Gorshkov |
|---|
| contact affiliation | V.L. Talrose Institute for Energy Problems of Chemical Physics, N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Leninsky Pr. 38, Bld.2, 119334, Moscow, Russia |
| contact email | mike.gorshkov@gmail.com |
| lab head | |
| Elizaveta Kazakova |
|---|
| contact affiliation | V. L. Talrose Institute for Energy Problems of Chemical Physics, N. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia |
| contact email | kazakovaem@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD060076 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD060076
- Label: PRIDE project
- Name: Ultrafast proteomics revealed everolimus-induced inhibition of 20S proteasome subunit
