⮝ Full datasets listing
PXD060067
PXD060067 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Effect of menstrual blood-derived mesenchymal stromal cell secretomes on macrophage polarization: therapeutic insights |
| Description | Menstrual blood-derived mesenchymal stromal cells (MenSCs) are a promising alternative source of MSCs for clinical applications due to their unique advantages, including easy isolation and high proliferative capacity. They possess immunomodulatory and regenerative capabilities, interacting with immune cells like macrophages and promoting tissue repair. While MenSCs hold therapeutic potential, cell-based therapies face limitations such as low survival rates and unpredictable paracrine activity. Therefore, utilizing the MenSC-derived secretome offers a potentially more effective therapeutic strategy. This study investigates the immunomodulatory capacity of the MenSC-derived secretome on macrophage differentiation, polarization, and repolarization. Here, label-free mass spectrometry analyses were conducted to identify the key immunomodulatory proteins involved in the effects of the MenSC-derived secretome. This research provides novel insights into the MenSC secretome's impact on macrophage modulation, paving the way for developing innovative cell-free therapies for immune and inflammatory diseases. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-02-02 |
| AnnouncementXML | Submission_2026-02-02_00:35:46.822.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Witold Szymanski |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized amino-terminal residue; L-methionine sulfoxide |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-22 06:28:47 | ID requested | |
| ⏵ 1 | 2026-02-02 00:35:47 | announced |
Publication List
| de Pedro M Á, L, ó, pez E, Gonz, á, lez-Nu, ñ, o FM, Pulido M, Á, lvarez V, Marchena AM, Preu, ß, er C, Szyma, ń, ski W, Pogge von Strandmann E, Graumann J, S, á, nchez-Margallo FM, Casado JG, G, ó, mez-Serrano M, Menstrual blood-derived mesenchymal stromal cells: impact of preconditioning on the cargo of extracellular vesicles as potential therapeutics. Stem Cell Res Ther, 14(1):187(2023) [pubmed] |
Keyword List
| submitter keyword: proteomics, timsTOF Pro, DIA, mesenchymal stromal cell, secretome, MSCs, MenSCs, macrophage differentiation, polarization of monocytes and macrophages, DatasetType:Proteomics |
Contact List
| Maria Gomez-Serrano | |
|---|---|
| contact affiliation | Center for Tumor Biology and Immunology, Philipps University, 35043 Marburg |
| contact email | gomezser@staff.uni-marburg.de |
| lab head | |
| Esther Lopez | |
| contact affiliation | Stem Cell Therapy Unit, Jesus Uson Minimally Invasive Surgery Centre, 10071 Caceres |
| contact email | elopez@ccmijesususon.com |
| lab head | |
| Witold Szymanski | |
| contact affiliation | Philipps-University Marburg Biochemical/Pharmacological Center Department of Medicine |
| contact email | witold.szymanski@uni-marburg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
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