PXD060032

PXD060032 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mouse islet ATG7 beta-cell knockout LC-MS/MS
Description	We knocked out the critical autophagy enzyme, ATG7, in the β-cells of mice (ATG7Δβ-cell) then monitored blood glucose to assess the phenotype induced by this KO model. We found that all ATG7Δβ-cell mice developed diabetes between 11-15 weeks of age. We isolated islets from ATG7Δβ-cell and littermate control mice several weeks prior to diabetes development (7-10 weeks of age) and performed bulk islet proteomics. The purpose of this experiment was to understand the islet biological process pathways altered by dysfunctional β-cell autophagy in the ATG7Δβ-cell model.
HostingRepository	PRIDE
AnnounceDate	2025-01-22
AnnouncementXML	Submission_2025-01-22_07:21:09.799.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Matt Austin
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; deamidated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-21 13:42:57	ID requested
⏵ 1	2025-01-22 07:21:10	announced

Publication List

10.3389/FIMMU.2025.1504583;

10.3389/FIMMU.2025.1504583;

Keyword List

submitter keyword: mouse islet, ATG7 beta-cell knockout, LC-MS/MS

submitter keyword: mouse islet, ATG7 beta-cell knockout, LC-MS/MS

Contact List

Amelia K. Linnemann
contact affiliation	Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States
contact email	aklinnem@iu.edu
lab head
Matt Austin
contact affiliation	Indiana University School of Medicine
contact email	mattaust@iu.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD060032
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD060032

PRIDE project URI

Repository Record List

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