PXD060021

PXD060021 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis revealed different characteristics of bladder cancer cells after exposure to bisphenol A
Description	Bisphenol A (BPA) is a widely used industrial chemical found in a variety of consumer products, including plastics, epoxy resins, and thermal paper. Recent studies have raised concerns about the potential adverse health effects of BPA, particularly its role in carcinogenesis. In this study, the toxic effects and its role in carcinogenesis of BPA were investigated in different bladder cancer cell lines (T24 and UMUC cells).Our findings demonstrate that BPA affects cell viability and migration in a dose-dependent manner. Low concentration of BPA significantly promotes cell migration in both T24 and UMUC cells, whereas a high concentration of BPA inhibits cell migration. Proteomics and transcriptomics analysis further revealed significant alterations in the protein and gene expression profiles in T24 and UMUC cells exposed to BPA. Bioinformatic analysis indicates the BPA may influence bladder cancer cell behavior through MAPK signal and inflammation response pathway. These findings collectively provide valuable insights into the molecular mechanisms underlying BPA-induced cellular changes, with implications for the development of more targeted and effective therapeutic strategies for cancer patients. Future research should focus on further elucidating the signaling pathways modulated by BPA, investigating potential synergistic or antagonistic effects with other environmental factors, and validating these findings through in vivo studies.
HostingRepository	PRIDE
AnnounceDate	2026-08-31
AnnouncementXML	Submission_2026-08-30_16:48:14.901.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	hanzhong feng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-21 07:07:23	ID requested
⏵ 1	2026-08-30 16:48:15	announced

10.1002/2211-5463.70221;

Niu S, Li L, Jia W, Feng H, Yu X, Zhao Y, Yuan F, Ding H, Tian J, He YX, Wang Z, Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A. FEBS Open Bio, 16(7):1428-1438(2026) [pubmed]

submitter keyword: proteomic,bladder cancer cells, bisphenol A

yongxing He
contact affiliation	Lanzhou University, Lanzhou, Gansu Province, China
contact email	heyx@lzu.edu.cn
lab head
hanzhong feng
contact affiliation	Lanzhou University
contact email	fenghzh19@lzu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD060021

PRIDE project URI

• PRIDE
  1. PXD060021
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analysis revealed different characteristics of bladder cancer cells after exposure to bisphenol A