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PXD060003

PXD060003 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe analysis of spermidine-binding proteins
DescriptionOur study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. This process is regulated by methionine metabolite spermidine,which can bind with proteins to regulate their biological function. Thus,the binding proteins of spermidine are detected in the presence or absence of Methionine for futher exploration。
HostingRepositoryiProX
AnnounceDate2025-01-21
AnnouncementXMLSubmission_2025-04-24_19:14:36.499.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJiawei Wu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Eclipse
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-01-20 19:30:48ID requested
12025-04-24 19:14:37announced
Publication List
Wu J, Ding C, Zhang C, Xu Z, Deng Z, Wei H, He T, Long L, Tang L, Ma J, Liang X, Methionine metabolite spermidine inhibits tumor pyroptosis by enhancing MYO6-mediated endocytosis. Nat Commun, 16(1):2184(2025) [pubmed]
Keyword List
submitter keyword: Human, HONE1 cells, Mass spectrometry
Contact List
Jun Ma
contact affiliationSun Yat-sen University Cancer Center
contact emailmajun2@mail.sysu.edu.cn
lab head
Jiawei Wu
contact affiliationSun Yat-sen University Cancer Center
contact emailgary1210@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI