PXD060003
PXD060003 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The analysis of spermidine-binding proteins |
| Description | Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. This process is regulated by methionine metabolite spermidine，which can bind with proteins to regulate their biological function. Thus，the binding proteins of spermidine are detected in the presence or absence of Methionine for futher exploration。 |
| HostingRepository | iProX |
| AnnounceDate | 2025-01-21 |
| AnnouncementXML | Submission_2025-04-24_19:14:36.499.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jiawei Wu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-20 19:30:48 | ID requested | |
| ⏵ 1 | 2025-04-24 19:14:37 | announced |
Publication List
| Wu J, Ding C, Zhang C, Xu Z, Deng Z, Wei H, He T, Long L, Tang L, Ma J, Liang X, Methionine metabolite spermidine inhibits tumor pyroptosis by enhancing MYO6-mediated endocytosis. Nat Commun, 16(1):2184(2025) [pubmed] |
Keyword List
| submitter keyword: Human, HONE1 cells, Mass spectrometry |
Contact List
| Jun Ma | |
|---|---|
| contact affiliation | Sun Yat-sen University Cancer Center |
| contact email | majun2@mail.sysu.edu.cn |
| lab head | |
| Jiawei Wu | |
| contact affiliation | Sun Yat-sen University Cancer Center |
| contact email | gary1210@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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