PXD059993

PXD059993 is an original dataset announced via ProteomeXchange.

Title	Multiomics reveals placental defect underlying preeclampsia
Description	Preeclampsia is a serious pregnancy-induced disorder unique to humans affecting 4.6% of pregnancies worldwide. Advances in the detection, prevention and treatment of preeclampsia have been poor due to our inadequate understanding of its pathogenesis. Here, we perform a multiomics study on early pregnancy placental biopsies (chorionic villus samples) from pregnancies that developed preterm and term preeclampsia compared to normotensive controls. Using an integrative statistical approach we discovered preterm preeclampsia was highly associated with lipoprotein metabolism whereas term preeclampsia was associated with inflammatory pathways and notch signaling. Melanophilin was identified as significantly reduced in early pregnancy placenta from term preeclampsia. Loss of melanophilin was required for syncytialization but excess loss disrupts syncytiotrophoblast function driving the production of antiangiogenic factors known to drive preeclampsia. Our study challenges the dogma that term preeclampsia is not associated with early placental pregnancy dysfunction and provides critical insight into the early pregnancy dysfunction underlying preeclampsia, opening up new avenues for predictive biomarker and preventative treatment discovery.
HostingRepository	PRIDE
AnnounceDate	2026-06-10
AnnouncementXML	Submission_2026-06-09_20:47:33.141.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yimiao Yu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Ascend; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-20 18:59:56	ID requested
⏵ 1	2026-06-09 20:47:34	announced

Menkhorst E, Yang G, Yu Y, Santos LL, Zhou W, Syngelaki A, Varshney S, Williamson NA, Koga K, Rolnik DL, da Silva Costa F, Nicolaides K, L, ê, Cao KA, Dimitriadis E, Multi-Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia. MedComm (2020), 7(6):e70784(2026) [pubmed]

10.1002/mco2.70784;

submitter keyword: multiomics,preeclampsia, placental defects, placenta, CVS

Eva Dimitriadis
contact affiliation	Royal Women's Hospital
contact email	evdokia.dimitriadis@unimelb.edu.au
lab head
Yimiao Yu
contact affiliation	Royal Women's Hospital
contact email	yimiaoy1@student.unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD059993

PRIDE project URI

• PRIDE
  1. PXD059993
     1. Label: PRIDE project
     2. Name: Multiomics reveals placental defect underlying preeclampsia