PXD059978 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ubiquitinome Profiling: Optimizing the enrichment and Data-Independent Analysis for Deeper Insights into Targeted Protein Degradation |
| Description | Targeted protein degradation has emerged as a highly promising therapeutic strategy for a wide range of diseases, including cancer and neurodegenerative disorders. The ubiquitin-proteasome system, which is responsible for protein degradation, plays a critical role in this process. Gaining comprehensive insights into the landscape of ubiquitination events is essential for the development of effective targeted protein degradation approaches. In recent years, data-independent analysis (DIA) has gained significant popularity as a robust and unbiased approach for quantitative proteomics. By leveraging on this method, we have developed a cutting-edge workflow that combines diGly antibody-based enrichment with an optimized Orbitrap-based data-independent acquisition method for the identification of ubiquitylated peptides. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-09 |
| AnnouncementXML | Submission_2026-06-09_06:24:28.025.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gajanan Sathe |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | ubiquitination signature dipeptidyl lysine |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-01-20 07:44:24 | ID requested | |
| ⏵ 1 | 2026-06-09 06:24:28 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Ubiquitination, DiGly, AdPROM,MAPT |
Contact List
| Prof Gopal Sapkota |
|---|
| contact affiliation | MRC PPU University of Dundee |
| contact email | g.sapkota@dundee.ac.uk |
| lab head | |
| Gajanan Sathe |
|---|
| contact affiliation | Centre for Targeted Protein Degradation (CeTPD)
University of Dundee |
| contact email | gsathe001@dundee.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD059978 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059978
- Label: PRIDE project
- Name: Ubiquitinome Profiling: Optimizing the enrichment and Data-Independent Analysis for Deeper Insights into Targeted Protein Degradation
