PXD059976

PXD059976 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Profiling of the proteome of peripheral blood mononuclear cells of subjects diagnosed with primary open angle glaucoma
Description	This study reports the first characterization of the intracellular proteome of peripheral blood mononuclear cells (PBMC) isolated from subjects diagnosed with primary open angle glaucoma (POAG)by shot-gun proteomics. Glaucoma is a chronic optic neuropathy and among the first causes of irreversible blindness on a global scale. Several recent data have pointed out alterations of immune system processes in glaucoma subjects. Very recently, oxygen consumption rate (OCR) and NAD levels have been proposed as biomarkers of disease severity.
HostingRepository	PRIDE
AnnounceDate	2025-09-22
AnnouncementXML	Submission_2025-09-22_10:17:19.943.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD059976
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Diego Sbardella
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 240

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-20 06:50:12	ID requested
⏵ 1	2025-09-22 10:17:20	announced

Publication List

Giammaria S, Pandino I, Zingale GA, Atzori MG, Cavaterra D, Cecere M, Michelessi M, Roberti G, Tanga L, Carnevale C, Vercellin AV, Siesky B, Harris A, Grasso G, Bocedi A, Coletta M, Tundo GR, Oddone F, Sbardella D, Profiling of the Peripheral Blood Mononuclear Cells Proteome by Shotgun Proteomics Identifies Alterations of Immune System Components, Proteolytic Balance, Autophagy, and Mitochondrial Metabolism in Glaucoma Subjects. ACS Omega, 10(15):14866-14883(2025) [pubmed]
10.1021/acsomega.4c10035;
10.6019/PXD059976;

Giammaria S, Pandino I, Zingale GA, Atzori MG, Cavaterra D, Cecere M, Michelessi M, Roberti G, Tanga L, Carnevale C, Vercellin AV, Siesky B, Harris A, Grasso G, Bocedi A, Coletta M, Tundo GR, Oddone F, Sbardella D, Profiling of the Peripheral Blood Mononuclear Cells Proteome by Shotgun Proteomics Identifies Alterations of Immune System Components, Proteolytic Balance, Autophagy, and Mitochondrial Metabolism in Glaucoma Subjects. ACS Omega, 10(15):14866-14883(2025) [pubmed]

10.1021/acsomega.4c10035;

10.6019/PXD059976;

Keyword List

submitter keyword: glaucoma, peripheral blood mononuclear cells, shot gun proteomics,Immune system

submitter keyword: glaucoma, peripheral blood mononuclear cells, shot gun proteomics,Immune system

Contact List

M.D. Ph.D. Diego Sbardella
contact affiliation	IRCCS Fondazione Bietti, Rome
contact email	diego.sbardella@fondazionebietti.it
lab head
Diego Sbardella
contact affiliation	IRCCS Fondazione Bietti
contact email	diego.sbardella@fondazionebietti.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD059976
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD059976

PRIDE project URI

Repository Record List

[ + ]