PXD059964

PXD059964 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Adiponectin influences the behavior of stem cells in hormone-resistant breast cancer
Description	Overcoming endocrine-resistance is the major challenge in treating Estrogen receptor (ER)-positive breast cancer. Breast Cancer Stem Cells (BCSCs) are blamed to be the driving force behind poor clinical outcomes and therapeutic resistance. Tumor microenvironment (TME) exerts a selective pressure on the tumor, supporting BCSCs behavior. The most prevalent cellular component of breast TME is represented by adipocytes, which secrete reduced levels of adiponectin in obesity, promoting ERα-positive breast cancer growth and progression. We examined the impact of low adiponectin levels on the enrichment of BCSC subpopulations and the molecular mechanisms by which this may contribute to hormone-resistance in breast cancer.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_06:31:39.777.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marco Gaspari
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-20 02:40:39	ID requested
⏵ 1	2025-05-07 06:31:40	announced

Publication List

10.3390/cells14040286;
Naimo GD, Forestiero M, Giordano F, Leonetti AE, Gelsomino L, Panno ML, And, ò S, Mauro L, Adiponectin Influences the Behavior of Stem Cells in Hormone-Resistant Breast Cancer. Cells, 14(4):(2025) [pubmed]

10.3390/cells14040286;

Naimo GD, Forestiero M, Giordano F, Leonetti AE, Gelsomino L, Panno ML, And, ò S, Mauro L, Adiponectin Influences the Behavior of Stem Cells in Hormone-Resistant Breast Cancer. Cells, 14(4):(2025) [pubmed]

Keyword List

submitter keyword: Breast cancer, Endocrine resistance, Cancer Stem Cells,: Adiponectin, Tamoxifen

submitter keyword: Breast cancer, Endocrine resistance, Cancer Stem Cells,: Adiponectin, Tamoxifen

Contact List

Marco Gaspari
contact affiliation	Research Centre for Advanced Biochemistry and Molecular Biology, Department of Experimental and Clinical Medicine, University of Catanzaro (IT)
contact email	gaspari@unicz.it
lab head
Marco Gaspari
contact affiliation	University of Catanzaro
contact email	gaspari@unicz.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059964
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059964

PRIDE project URI

Repository Record List

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