PXD059943

PXD059943 is an original dataset announced via ProteomeXchange.

Title	Pathological changes in extracellular matrix composition orchestrate the fibrotic feedback loop through macrophage activation in Dupuytren’s contracture
Description	Dupuytren’s contracture belongs to a large group of fibrotic diseases that share similar mechanisms but lack effective treatment and prevention options. Unlike fibrotic diseases affecting internal organs such as the heart, lung or liver which are typically diagnosed at later stages when the functions of the organ are irreversibly impaired, DD tissue can be diagnosed early and is readily accessible for scientific research after surgical excision. This enables us to analyse the mechanism of active fibrotic process in the relatively early-stage nodular tissue ex vivo. Here we described the changes in ECM-associated proteome of DD tissue and identified the components that potentially activate or promote the fibrosis in DD. Furthermore, our results indicate that the pathological changes in diseased ECM composition orchestrate a feedback loop through macrophage activation which promotes myofibroblast activation and differentiation.
HostingRepository	PRIDE
AnnounceDate	2025-03-29
AnnouncementXML	Submission_2025-03-29_06:42:37.142.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mariliis Klaas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-19 14:27:53	ID requested
⏵ 1	2025-03-29 06:42:37	announced

10.3390/IJMS26073146;

submitter keyword: Dupuytren's contracture,fibrosis, extracellular matrix, decellularization

Mariliis Klaas
contact affiliation	Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia
contact email	mariliis.klaas@ut.ee
lab head
Mariliis Klaas
contact affiliation	University of Tartu
contact email	mariliis.klaas@ut.ee
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD059943

PRIDE project URI

• PRIDE
  1. PXD059943
     1. Label: PRIDE project
     2. Name: Pathological changes in extracellular matrix composition orchestrate the fibrotic feedback loop through macrophage activation in Dupuytren’s contracture