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PXD059943

PXD059943 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePathological changes in extracellular matrix composition orchestrate the fibrotic feedback loop through macrophage activation in Dupuytren’s contracture
DescriptionDupuytren’s contracture belongs to a large group of fibrotic diseases that share similar mechanisms but lack effective treatment and prevention options. Unlike fibrotic diseases affecting internal organs such as the heart, lung or liver which are typically diagnosed at later stages when the functions of the organ are irreversibly impaired, DD tissue can be diagnosed early and is readily accessible for scientific research after surgical excision. This enables us to analyse the mechanism of active fibrotic process in the relatively early-stage nodular tissue ex vivo. Here we described the changes in ECM-associated proteome of DD tissue and identified the components that potentially activate or promote the fibrosis in DD. Furthermore, our results indicate that the pathological changes in diseased ECM composition orchestrate a feedback loop through macrophage activation which promotes myofibroblast activation and differentiation.
HostingRepositoryPRIDE
AnnounceDate2025-03-29
AnnouncementXMLSubmission_2025-03-29_06:42:37.142.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMariliis Klaas
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-01-19 14:27:53ID requested
12025-03-29 06:42:37announced
Publication List
10.3390/IJMS26073146;
Keyword List
submitter keyword: Dupuytren's contracture,fibrosis, extracellular matrix, decellularization
Contact List
Mariliis Klaas
contact affiliationInstitute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia
contact emailmariliis.klaas@ut.ee
lab head
Mariliis Klaas
contact affiliationUniversity of Tartu
contact emailmariliis.klaas@ut.ee
dataset submitter
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Dataset FTP location
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