PXD059943 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Pathological changes in extracellular matrix composition orchestrate the fibrotic feedback loop through macrophage activation in Dupuytren’s contracture |
Description | Dupuytren’s contracture belongs to a large group of fibrotic diseases that share similar mechanisms but lack effective treatment and prevention options. Unlike fibrotic diseases affecting internal organs such as the heart, lung or liver which are typically diagnosed at later stages when the functions of the organ are irreversibly impaired, DD tissue can be diagnosed early and is readily accessible for scientific research after surgical excision. This enables us to analyse the mechanism of active fibrotic process in the relatively early-stage nodular tissue ex vivo. Here we described the changes in ECM-associated proteome of DD tissue and identified the components that potentially activate or promote the fibrosis in DD. Furthermore, our results indicate that the pathological changes in diseased ECM composition orchestrate a feedback loop through macrophage activation which promotes myofibroblast activation and differentiation. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-29 |
AnnouncementXML | Submission_2025-03-29_06:42:37.142.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mariliis Klaas |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-01-19 14:27:53 | ID requested | |
⏵ 1 | 2025-03-29 06:42:37 | announced | |
Publication List
Keyword List
submitter keyword: Dupuytren's contracture,fibrosis, extracellular matrix, decellularization |
Contact List
Mariliis Klaas |
contact affiliation | Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia |
contact email | mariliis.klaas@ut.ee |
lab head | |
Mariliis Klaas |
contact affiliation | University of Tartu |
contact email | mariliis.klaas@ut.ee |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/03/PXD059943 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059943
- Label: PRIDE project
- Name: Pathological changes in extracellular matrix composition orchestrate the fibrotic feedback loop through macrophage activation in Dupuytren’s contracture