PXD059940

PXD059940 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Characterisation of directed maturation in human cardiac organoids
Description	Cardiac maturation is an important developmental phase where there are profound biological and functional changes after birth in mammals. Herein, we use our profiling of human heart maturation in vivo to identify key drivers of maturation in our human cardiac organoid (hCO) model. After screening of various metabolism modulating factors, we established a directed maturation (DM) protocol to induce mature cardiac expression and compared the proteomic changes to our original serum free (SF) protocol. In this dataset, we compared 4 replicates of DM to 4 replicates of SF derived cardiac organoids using global DIA-MS/MS.
HostingRepository	PRIDE
AnnounceDate	2025-04-17
AnnouncementXML	Submission_2025-04-16_16:51:55.430.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Harley Robinson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF; Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-18 22:39:03	ID requested
⏵ 1	2025-04-16 16:51:55	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: maturation,Cardiac organoids

submitter keyword: maturation,Cardiac organoids

Contact List

Prof James Hudson
contact affiliation	Cardiac Bioengineering Lab, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AUS
contact email	james.hudson@qimrberghofer.edu.au
lab head
Harley Robinson
contact affiliation	QIMR Berghofer Medical Research Institute
contact email	Harley.robinson@uqconnect.edu.au
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD059940
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD059940

PRIDE project URI

Repository Record List

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