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PXD059940

PXD059940 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCharacterisation of directed maturation in human cardiac organoids
DescriptionCardiac maturation is an important developmental phase where there are profound biological and functional changes after birth in mammals. Herein, we use our profiling of human heart maturation in vivo to identify key drivers of maturation in our human cardiac organoid (hCO) model. After screening of various metabolism modulating factors, we established a directed maturation (DM) protocol to induce mature cardiac expression and compared the proteomic changes to our original serum free (SF) protocol. In this dataset, we compared 4 replicates of DM to 4 replicates of SF derived cardiac organoids using global DIA-MS/MS.
HostingRepositoryPRIDE
AnnounceDate2025-04-17
AnnouncementXMLSubmission_2025-04-16_16:51:55.430.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHarley Robinson
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-01-18 22:39:03ID requested
12025-04-16 16:51:55announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: maturation,Cardiac organoids
Contact List
Prof James Hudson
contact affiliationCardiac Bioengineering Lab, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AUS
contact emailjames.hudson@qimrberghofer.edu.au
lab head
Harley Robinson
contact affiliationQIMR Berghofer Medical Research Institute
contact emailHarley.robinson@uqconnect.edu.au
dataset submitter
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Dataset FTP location
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PRIDE project URI
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