PXD059907

PXD059907 is an original dataset announced via ProteomeXchange.

Title	Injured tubular cells mediate neutrophil migration via Spp1/Cd44 interaction and upregulate Npm1 to promote tubular regeneration in AKI
Description	An AKI model was induced by unilateral ischemia-reperfusion injury (uIRI) in mice, and a hypoxia/reoxygenation (H/R) model was established using TCMK-1 renal tubular epithelial cells. Transwell migration assays were conducted to validate the effect of Spp1/Cd44 interaction on peripheral blood neutrophil (PMN) migration. Proteomic analyses were used to assess protein abundance related to tubular cell regeneration. We examined the differences in protein expression in the supernatants of TCMK-1 cells co-cultured with PMNs and TCMK-1 cells cultured alone in the Transwell system.
HostingRepository	iProX
AnnounceDate	2025-01-16
AnnouncementXML	Submission_2025-01-16_18:38:11.917.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiayu Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-16 18:36:35	ID requested
⏵ 1	2025-01-16 18:38:12	announced

Dataset with its publication pending

submitter keyword: Acute Kidney Injury (AKI), Neutrophil Migration, Spp1/Cd44 Interaction, Nucleophosmin 1 (Npm1), Tubular Cell Regeneration, 5-aminosalicylic acid (5-ASA)

Xiaopeng Hu
contact affiliation	Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University
contact email	xiaopeng_hu@sina.com
lab head
Jiayu Wang
contact affiliation	Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University
contact email	doc_jiayu@163.com
dataset submitter

iProX dataset URI