PXD059906

PXD059906 is an original dataset announced via ProteomeXchange.

Title	Proteomics and phosphoproteomics reveal dysregulated kinases and associated pathway in liver fibrosis
Description	Liver fibrosis is the initial stage of most liver diseases, and it is also a pathological process involving the liver in the late stages of many metabolic diseases. Therefore, it is important to systematically understand the pathological mechanism of liver fibrosis and seek therapeutic approaches for intervention and treatment of liver fibrosis. Disorder proteins and their post-translational modifications such as phosphorylation play vital roles in the occurrence and development of liver fibrosis, however, the regulatory mechanisms are not fully understood. In this study, we analyzed and quantified the liver proteome and phosphoproteome of CCl4-induced early liver fibrosis in mice.
HostingRepository	iProX
AnnounceDate	2025-01-16
AnnouncementXML	Submission_2025-12-16_01:29:48.052.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanchang Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480; Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-16 18:34:07	ID requested
⏵ 1	2025-12-16 01:29:49	announced

Cheng X, Kang L, Liu J, Wang Q, Zhang Z, Zhang L, Xie Y, Chang L, Zeng D, Tian L, Zhang L, Xu P, Li Y, Proteomics and Phosphoproteomics Revealed Dysregulated Kinases and Potential Therapy for Liver Fibrosis. Mol Cell Proteomics, 24(6):100991(2025) [pubmed]

submitter keyword: Proteomics, phosphoproteomics, kinases, liver fibrosis

Yanchang Li
contact affiliation	Beijing Proteome Research Center
contact email	liyanchang1017@163.com
lab head
Yanchang Li
contact affiliation	Beijing Proteome Research Center
contact email	liyanchang1017@163.com
dataset submitter

iProX dataset URI