PXD059849

PXD059849 is an original dataset announced via ProteomeXchange.

Title	Dynamic proteomic profiling and biomarker identification in twin preeclampsia
Description	This study aimed to explore the proteomic changes in twin pregnancies complicated with preeclampsia (PE) and identify potential biomarkers for early detection. Maternal plasma samples from twin pregnancies with PE (PE1, PE2, PE3) and healthy controls (CON1, CON2, CON3) were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The expression were further validated and investigated using cell-based assay. Differential proteins were identified, and bioinformatics analysis was performed to elucidate the involved pathways. Our results provide valuable insights into the molecular mechanisms of twin PE and potential biomarkers for clinical application.
HostingRepository	iProX
AnnounceDate	2025-01-15
AnnouncementXML	Submission_2025-01-15_21:58:30.865.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haohao Tang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-15 21:58:07	ID requested
⏵ 1	2025-01-15 21:58:31	announced

Dataset with its publication pending

submitter keyword: proteomic biomarker twin preeclampsia

Yang Chen
contact affiliation	Peking University Health Science Center
contact email	chenyang1816185048@bjmu.edu.cn
lab head
Haohao Tang
contact affiliation	Peking University Health Science Center
contact email	Tanghaohao0987@163.com
dataset submitter

iProX dataset URI