PXD059804
PXD059804 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Integrative Omics Analysis Reveals Specific Hepatic Metabolic Adaption During Prolonged Cyclic Calorie Restriction |
Description | In this study, we designed a weekly intermittent calorie restriction cycle: 50% reduction on days 1 and 4, 70% on days 2 and 3, and unrestricted eating on days 5 to 7. This pattern mimics feasible non-linear CR observed in humans. To evaluate metabolic outcomes, high-fat diets (HFD) were utilized to induce obesity and related metabolic disorders, providing a robust model for assessing the efficacy of CR interventions. Liver samples from the ad libitum (AL) control group and low-calorie (LC, Day3 of the cycle) and refeeding (RF, Day7 of the cycle) phases from the calorie-restricted group were examined via RNAseq |
HostingRepository | iProX |
AnnounceDate | 2025-01-15 |
AnnouncementXML | Submission_2025-01-14_22:37:02.522.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yifan Tu |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-01-14 22:36:42 | ID requested | |
⏵ 1 | 2025-01-14 22:37:02 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Proteomics, Metabolic Adaption, Calorie Restriction |
Contact List
Man Yuen Lee | |
---|---|
contact affiliation | The Hong Kong Polytechnic University |
contact email | leomylee@gmail.com |
lab head | |
Yifan Tu | |
contact affiliation | Hong Kong Polytechnic University |
contact email | yifan.tu@polyu.edu.hk |
dataset submitter |
Full Dataset Link List
iProX dataset URI |