PXD059749
PXD059749 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Caffeoylquinic acids from sweetpotato (Ipomoea batatas L.) leaves ameliorates immune thrombocytopenia by regulating Th17/Treg balance |
Description | Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by antiplatelet autoantibodies, thrombocytopenia, and bleeding, however, its treatment options are limited. In this study, a kind of active component, caffeoylquinic acid compounds from sweetpotato leaves was extracted out to explore its medicinal value and provide novel therapeutic strategies for the treatment of ITP. We isolated three compounds from the n-butanol extract of sweetpotato leaves. Caffeoylquinic acids could participate the immune balance of T-helper 17 lymphocytes (Th17) / regulatory T cells (Treg) in a murine model of ITP, which was established by injection of antiplatelet antibody. Further quantitative proteomics analysis revealed that caffeoylquinic acid could activate AMPK signaling pathway. It suggested that caffeoylquinic acid may provide a novel therapeutic strategy that relies on the AMPK pathway. |
HostingRepository | iProX |
AnnounceDate | 2025-01-13 |
AnnouncementXML | Submission_2025-01-13_18:39:55.420.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yi Zhang |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2025-01-13 18:39:32 | ID requested | |
⏵ 1 | 2025-01-13 18:39:55 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: sweetpotato leaves, caffeoylquinic acid, T-helper 17 lymphocytes, regulatory T cells |
Contact List
Jian Sun | |
---|---|
contact affiliation | Jiangsu Normal University |
contact email | zhangyijsnu@163.com |
lab head | |
Yi Zhang | |
contact affiliation | Jiangsu Normal University |
contact email | zhangyijsnu@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |