PXD059749

PXD059749 is an original dataset announced via ProteomeXchange.

Title	Caffeoylquinic acids from sweetpotato (Ipomoea batatas L.) leaves ameliorates immune thrombocytopenia by regulating Th17/Treg balance
Description	Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by antiplatelet autoantibodies, thrombocytopenia, and bleeding, however, its treatment options are limited. In this study, a kind of active component, caffeoylquinic acid compounds from sweetpotato leaves was extracted out to explore its medicinal value and provide novel therapeutic strategies for the treatment of ITP. We isolated three compounds from the n-butanol extract of sweetpotato leaves. Caffeoylquinic acids could participate the immune balance of T-helper 17 lymphocytes (Th17) / regulatory T cells (Treg) in a murine model of ITP, which was established by injection of antiplatelet antibody. Further quantitative proteomics analysis revealed that caffeoylquinic acid could activate AMPK signaling pathway. It suggested that caffeoylquinic acid may provide a novel therapeutic strategy that relies on the AMPK pathway.
HostingRepository	iProX
AnnounceDate	2025-01-13
AnnouncementXML	Submission_2025-01-13_18:39:55.420.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-13 18:39:32	ID requested
⏵ 1	2025-01-13 18:39:55	announced

Dataset with its publication pending

submitter keyword: sweetpotato leaves, caffeoylquinic acid, T-helper 17 lymphocytes, regulatory T cells

Jian Sun
contact affiliation	Jiangsu Normal University
contact email	zhangyijsnu@163.com
lab head
Yi Zhang
contact affiliation	Jiangsu Normal University
contact email	zhangyijsnu@163.com
dataset submitter

iProX dataset URI