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PXD059749

PXD059749 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCaffeoylquinic acids from sweetpotato (Ipomoea batatas L.) leaves ameliorates immune thrombocytopenia by regulating Th17/Treg balance
DescriptionIdiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by antiplatelet autoantibodies, thrombocytopenia, and bleeding, however, its treatment options are limited. In this study, a kind of active component, caffeoylquinic acid compounds from sweetpotato leaves was extracted out to explore its medicinal value and provide novel therapeutic strategies for the treatment of ITP. We isolated three compounds from the n-butanol extract of sweetpotato leaves. Caffeoylquinic acids could participate the immune balance of T-helper 17 lymphocytes (Th17) / regulatory T cells (Treg) in a murine model of ITP, which was established by injection of antiplatelet antibody. Further quantitative proteomics analysis revealed that caffeoylquinic acid could activate AMPK signaling pathway. It suggested that caffeoylquinic acid may provide a novel therapeutic strategy that relies on the AMPK pathway.
HostingRepositoryiProX
AnnounceDate2025-01-13
AnnouncementXMLSubmission_2025-01-13_18:39:55.420.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYi Zhang
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-01-13 18:39:32ID requested
12025-01-13 18:39:55announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: sweetpotato leaves, caffeoylquinic acid, T-helper 17 lymphocytes, regulatory T cells
Contact List
Jian Sun
contact affiliationJiangsu Normal University
contact emailzhangyijsnu@163.com
lab head
Yi Zhang
contact affiliationJiangsu Normal University
contact emailzhangyijsnu@163.com
dataset submitter
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