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PXD059743
PXD059743 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparing the Effects of Taurine and 3-Sulfopropanoic Acid, a Metabolite of Tramiprosate, on ApoE4 Pathological Aggregation: Implications for Alzheimer's Disease |
| Description | Apolipoprotein E4 (ApoE4) is a major genetic risk factor for Alzheimer's disease. Its pathological aggregation can be mitigated by tramiprosate and its metabolite 3-sulfopropanoic acid, along with their impact on the transcription of genes, expression of proteins, and production of lipids. Taurine is a close chemical analogue of tramiprosate with an extra carbon atom, demonstrating protective effects against aging. Using an integrated approach involving static light scattering, hydrogen-deuterium exchange mass spectrometry, molecular dynamics, and studies of cerebral organoids, we evaluated the effects of 3-sulfopropanoic acid and taurine on ApoE4 aggregation, as well as their impact on organoid transcriptomics and proteomics. Our results reveal that taurine effectively inhibits ApoE4 aggregation, comparable to 3-sulfopropanoic acid, and ameliorates the pathophysiological phenotype of ApoE4 in cerebral organoids, aligning it more closely with the ApoE3 phenotype. These findings suggest that taurine may have potential as a therapeutic agent against Alzheimer's disease, particularly in ApoE4/E4 carriers. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2026-07-02 |
| AnnouncementXML | Submission_2026-07-02_11:08:26.442.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Marketa Nezvedova |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | Label:13C(6)15N(2); Label:13C(6)15N(4) |
| Instrument | 6495B Triple Quadrupole LC/MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-13 17:17:07 | ID requested | |
| ⏵ 1 | 2026-07-02 11:08:26 | announced |
Publication List
| Anthony Legrand, Katerina Amruz Cerna, Sérgio M. Marques, Naina Verma, Jakub Kopko, Tereza Vanova, Madhumalar Subramanian, Aliaksandra Kursit, Jaroslav Bendl, Tomas Henek, Pavel Vanacek, Josef Kucera, Joan Planas-Iglesias, Jiri Sedmik, Veronika Pospisilova, Petr Kouba, Aneta Vaskova, Marketa Nezvedova, Jiri Sedlar, Jiri Damborsky, Stanislav Mazurenko, Martin Marek, Josef Sivic, Lenka Hernychova, David Bednar, Dasa Bohaciakova, Zbynek Prokop, Taurine inhibits apolipoprotein E4 aggregation, Biomedicine & Pharmacotherapy, Volume 199, 2026, 119395, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2026.119395. (https://www.sciencedirect.com/science/article/pii/S0753332226004300) |
Keyword List
| submitter keyword: aggregation, Alzheimer's disease, apolipoprotein E4, taurine, therapeutic potential |
Contact List
| Marketa Nezvedova | |
|---|---|
| contact affiliation | RECETOX, Faculty of Science, MUNI |
| contact email | marketa.nezvedova@recetox.muni.cz |
| lab head | |
| Marketa Nezvedova | |
| contact affiliation | RECETOX, Faculty of Science, MUNI |
| contact email | marketa.nezvedova@recetox.muni.cz |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
