PXD059728

PXD059728 is an original dataset announced via ProteomeXchange.

Title	In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer
Description	Late-stage and advanced colorectal cancer (CRC) often prove to be resistant to current treatment regimens, due to the evolving tumor microenvironment. Chemotherapy-dominated multi-modal therapeutic strategies based on the specific CRC microenvironment open a new horizon for eradicating colorectal tumors. Here, in situ valence-transited arsenic nanosheets are developed as a multi-modal therapeutic platform by responding to the H2S-enriched CRC microenvironment. Carrier-free pegylated nanosheets of pentavalent arsenic (AsV), aminooxyacetic acid (AOAA), and copper ion (Cu2+) are innovatively self-assembled via coordination with high loading content and good stability. AsV in pegylated arsenic nanosheets (CAA-PEG NSs) is rapidly released and reduced to trivalent arsenic (AsIII) to exert its chemotherapy in the local tumor. Furthermore, the immunosuppressive microenvironment is thoroughly remodeled via H2S depletion of AsV to AsIII conversion and impairment of H2S production by AOAA. Additionally, the in situ produced ultrasmall CuS nanoparticles exhibit photothermal activity against CRC under the guidance of photoacoustic imaging. This multi-modal therapeutic strategy, dominated by chemotherapy, completely inhibits CRC progression and prevents its relapse.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-07_06:28:48.515.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lai Jiang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-13 05:31:03	ID requested
⏵ 1	2025-05-07 06:28:49	announced

Zheng H, Zhang K, Piao J, Mu C, Xie X, Cheng M, Yue T, Sun J, Li B, Wei Y, Zheng H, Jiang L, Habiballah DN, Li F, In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer. Nat Commun, 16(1):2088(2025) [pubmed]

10.1038/s41467-025-57376-7;

submitter keyword: in situ microenvironment response, colorectal cancer treatment., multi-modal therapy,arsenic valence transition

Fanzhu Li
contact affiliation	School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 311402, China
contact email	1355031732@qq.com
lab head
Lai Jiang
contact affiliation	Zhejiang Chinese Medical University
contact email	1355031732@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD059728

PRIDE project URI

• PRIDE
  1. PXD059728
     1. Label: PRIDE project
     2. Name: In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer