PXD059728 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer |
Description | Late-stage and advanced colorectal cancer (CRC) often prove to be resistant to current treatment regimens, due to the evolving tumor microenvironment. Chemotherapy-dominated multi-modal therapeutic strategies based on the specific CRC microenvironment open a new horizon for eradicating colorectal tumors. Here, in situ valence-transited arsenic nanosheets are developed as a multi-modal therapeutic platform by responding to the H2S-enriched CRC microenvironment. Carrier-free pegylated nanosheets of pentavalent arsenic (AsV), aminooxyacetic acid (AOAA), and copper ion (Cu2+) are innovatively self-assembled via coordination with high loading content and good stability. AsV in pegylated arsenic nanosheets (CAA-PEG NSs) is rapidly released and reduced to trivalent arsenic (AsIII) to exert its chemotherapy in the local tumor. Furthermore, the immunosuppressive microenvironment is thoroughly remodeled via H2S depletion of AsV to AsIII conversion and impairment of H2S production by AOAA. Additionally, the in situ produced ultrasmall CuS nanoparticles exhibit photothermal activity against CRC under the guidance of photoacoustic imaging. This multi-modal therapeutic strategy, dominated by chemotherapy, completely inhibits CRC progression and prevents its relapse. |
HostingRepository | PRIDE |
AnnounceDate | 2025-05-07 |
AnnouncementXML | Submission_2025-05-07_06:28:48.515.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lai Jiang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2025-01-13 05:31:03 | ID requested | |
⏵ 1 | 2025-05-07 06:28:49 | announced | |
Publication List
Zheng H, Zhang K, Piao J, Mu C, Xie X, Cheng M, Yue T, Sun J, Li B, Wei Y, Zheng H, Jiang L, Habiballah DN, Li F, In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer. Nat Commun, 16(1):2088(2025) [pubmed] |
10.1038/s41467-025-57376-7; |
Keyword List
submitter keyword: in situ microenvironment response, colorectal cancer treatment., multi-modal therapy,arsenic valence transition |
Contact List
Fanzhu Li |
contact affiliation | School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 311402, China |
contact email | 1355031732@qq.com |
lab head | |
Lai Jiang |
contact affiliation | Zhejiang Chinese Medical University |
contact email | 1355031732@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD059728
- Label: PRIDE project
- Name: In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer