PXD059722

PXD059722 is an original dataset announced via ProteomeXchange.

Title	Top down analysis of human MT2 modification by ajoen and allicine
Description	Garlic (Allium sativum) is a widely used culinary ingredient of multiple cuisines. Once disintegrated garlic cloves release volatile sulfur compounds, the so-called garlic organosulfur compounds (GOSC). The most famous of these are allicin and ajoen, known for their antimicrobial properties. These compounds also readily modify human metallothionein proteins. In this study we aimed to identify the reactive sites of allicin and ajoen within the purified human metallothionein 2 (MT2). For this we employed an LC-MS protein top-down analysis.
HostingRepository	PRIDE
AnnounceDate	2025-07-31
AnnouncementXML	Submission_2025-07-31_00:07:49.215.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michał Tracz
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	disulfide conjugated residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2025-01-13 03:13:51	ID requested
⏵ 1	2025-07-31 00:07:49	announced

10.1007/S10534-025-00716-3;

submitter keyword: metallothionein MT2 allicin ajoen GOSC Allium sativum garlic organosulfur compounds top down modification

Michal Tracz
contact affiliation	Laboratory of Protein Mass Spectrometry, Faculty of Biotechnology, University of Wroclaw
contact email	michal.tracz2@uwr.edu.pl
lab head
Michał Tracz
contact affiliation	Laboratory of Mass Spectrometry, Faculty of Biotechnology, University of Wroclaw
contact email	michal.tracz2@uwr.edu.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD059722

PRIDE project URI

• PRIDE
  1. PXD059722
     1. Label: PRIDE project
     2. Name: Top down analysis of human MT2 modification by ajoen and allicine